Subijiang Tuerxun, Yao Xiao-Guang, Wu Ting, Mulalibieke Heizhati, Buayixianmu Aimaiti
Hypertension Center of People's Hospital of Xinjiang Uygur Autonomous Region,Urumqi 830001,China.
Key Laboratory of Xinjiang Uygur Autonomous Region,Hypertension Research Laboratory,Urumqi 830001,China.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2025 Aug;47(4):567-574. doi: 10.3881/j.issn.1000-503X.16483.
Objective To investigate the correlations of circulating miRNA-205 expression with systemic immune-inflammation index(SII)and systemic inflammation response index(SIRI)in patients with severe obstructive sleep apnea(OSA). Methods The patients who attended the Hypertension Center of the People's Hospital of Xinjiang Uygur Autonomous Region from January to June 2023 and underwent complete overnight polysomnography were consecutively included in this study.Among them,30 patients had severe OSA,and 32 patients did not have OSA.Blood routine tests(white blood cells,neutrophils,monocytes,platelets,etc.)were performed and the expression of miRNA-205 was determined by quantitative reverse transcription PCR.Simple regression was adopted to analyze the correlations among miRNA-205,SII,SIRI,and OSA parameters.The potential regulatory effects of miRNA-205 on OSA and inflammation indices were further evaluated. Results The patients with severe OSA showed lower expression of circulating miRNA-205[1.910(1.240,2.403)3.650(2.148,5.109),=-3.874,<0.001]and higher SIRI[1.090(0.775,1.573)0.870(0.650,1.240),=-2.031,=0.041]and SII[555.200(451.780,936.350)448.685(380.823,646.073),=-2.029,=0.042]than non-OSA patients.In the whole population,apnea-hypopnea index(AHI)showed a negative correlation with circulating miRNA-205(=-0.391,=0.002).Among severe OSA patients,each 1-unit increase in AHI was associated with a reduction of 0.030 in miRNA-205 and increases of 10.046 and 0.037 in SII and SIRI,respectively(SII:=0.003;SIRI:=0.037).Conversely,each 1-unit rise in miRNA-205 predicted a decrease of 121.093 in SII(=-0.40,=0.046).The low expression of miRNA-205 might have a negative moderating effect on elevated SII(=-0.40,=0.004). Conclusions Compared with the patients without OSA,those with severe OSA showed elevated SII and SIRI and down-regulated expression of miRNA-205.The low expression of miRNA-205 might have a negative moderating effect on the systemic inflammatory state associated with severe OSA.
目的 探讨重度阻塞性睡眠呼吸暂停（OSA）患者循环miRNA-205表达与全身免疫炎症指数（SII）和全身炎症反应指数（SIRI）的相关性。方法 连续纳入2023年1月至6月在新疆维吾尔自治区人民医院高血压中心就诊并接受整夜多导睡眠图检查的患者。其中，重度OSA患者30例，非OSA患者32例。进行血常规检查（白细胞、中性粒细胞、单核细胞、血小板等），采用定量逆转录PCR法检测miRNA-205的表达。采用简单回归分析miRNA-205、SII、SIRI和OSA参数之间的相关性。进一步评估miRNA-205对OSA和炎症指标的潜在调节作用。结果 重度OSA患者循环miRNA-205表达较低[1.910（1.240，2.403）对3.650（2.148，5.109），Z=-3.874，P<0.001]，SIRI[1.090（0.775，1.573）对0.870（0.650，1.240），Z=-2.031，P=0.041]和SII[555.200（451.780，936.350）对448.685（380.823，646.073），Z=-2.029，P=0.042]高于非OSA患者。在总体人群中，呼吸暂停低通气指数（AHI）与循环miRNA-205呈负相关（r=-0.391，P=0.002）。在重度OSA患者中，AHI每增加1个单位，miRNA-205降低0.030，SII和SIRI分别增加10.046和0.037（SII：β=0.003；SIRI：β=0.037）。相反，miRNA-205每升高1个单位，预测SII降低121.093（β=-0.40，P=0.046）。miRNA-205低表达可能对升高的SII有负向调节作用（β=-0.40，P=0.004）。结论 与无OSA患者相比，重度OSA患者SII和SIRI升高，miRNA-205表达下调。miRNA-205低表达可能对重度OSA相关的全身炎症状态有负向调节作用。
