观点：对多基因常见可变免疫缺陷样疾病的不断演变的认识 - Suppr

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Opinion: the evolving understanding of polygenic common variable immunodeficiency-like disorders.

作者信息

Ameratunga Rohan, Leung Euphemia Yee, Longhurst Hilary J, Lehnert Klaus, Woon See-Tarn

机构信息

Department of Clinical Immunology, Auckland Hospital, Auckland, New Zealand.

Department of Virology and Immunology, Auckland Hospital, Auckland, New Zealand.

出版信息

Front Immunol. 2025 Aug 28;16:1618482. doi: 10.3389/fimmu.2025.1618482. eCollection 2025.

DOI:10.3389/fimmu.2025.1618482

PMID:40948799

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12423029/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bad4/12423029/b5a239546881/fimmu-16-1618482-g001.jpg

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The Rapidly Expanding Genetic Spectrum of Common Variable Immunodeficiency-Like Disorders.常见可变免疫缺陷样疾病的遗传谱迅速扩大。

J Allergy Clin Immunol Pract. 2023 Jun;11(6):1646-1664. doi: 10.1016/j.jaip.2023.01.048. Epub 2023 Feb 14.

Human Inborn Errors of Immunity: 2022 Update on the Classification from the International Union of Immunological Societies Expert Committee.人类先天性免疫缺陷：国际免疫学联盟专家委员会 2022 年更新的分类。

J Clin Immunol. 2022 Oct;42(7):1473-1507. doi: 10.1007/s10875-022-01289-3. Epub 2022 Jun 24.

Are All Primary Immunodeficiency Disorders Inborn Errors of Immunity?所有原发性免疫缺陷病都是先天性免疫缺陷吗？

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Humans with inherited T cell CD28 deficiency are susceptible to skin papillomaviruses but are otherwise healthy.遗传性 T 细胞 CD28 缺陷的人易患皮肤乳头瘤病毒，但其他方面健康。

Cell. 2021 Jul 8;184(14):3812-3828.e30. doi: 10.1016/j.cell.2021.06.004. Epub 2021 Jul 1.

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Assessing Disease Severity in Common Variable Immunodeficiency Disorders (CVID) and CVID-Like Disorders.评估常见可变免疫缺陷病（CVID）及类CVID疾病的疾病严重程度。

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