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非法药物——感染与新生儿人体测量特征。

Illicit drugs - infections and neonatal anthropometric characteristics.

作者信息

Năstase Leonard, Stoicescu Silvia-Maria, Suciu Nicolae, Bohîlţea Laurenţiu Camil, Panaitescu Eugenia, Baciu Adina-Brânduşa

机构信息

PhD, Carol Davila University of Medicine and Pharmacy, Bucharest, 050474, Romania and "Alessandrescu-Rusescu" National Institute for Mother and Child Health, Bucharest, Romania.

PhD, Professor, Carol Davila University of Medicine and Pharmacy, Bucharest, 050474, Romania and "Alessandrescu Rusescu" National Institute for Mother and Child Health, Bucharest, Romania.

出版信息

Germs. 2025 Jun 30;15(2):157-165. doi: 10.18683/germs.2025.1465. eCollection 2025 Jun.

Abstract

INTRODUCTION

The effects of drug addiction in pregnancy are associated with multiple maternal, fetal and neonatal risks in the short and long term.

METHODS

This was a retrospective descriptive study conducted in the National Institute for Maternal and Child Health "Alessandrescu-Rusescu" Bucharest, Romania - "Polizu" Hospital of Obstetrics and Gynecology (higher level maternity hospital), includes newborns from the last 22 years (2002-2024) from mothers who used illicit drugs before and during pregnancy.

RESULTS

The incidence of newborns born to mothers with drug addiction has steadily increased over the period studied, especially in the last 12 years. Neonatal morbidity was marked by: withdrawal syndrome (61.2% of cases), risk of congenital/perinatal infections through maternal infections (58.16%), prematurity (43.87%), birth weight ≤2500g (55.10%), intrauterine growth restriction.

CONCLUSIONS

Illicit drug use in pregnancy, associated with prematurity, intrauterine growth restriction, neonatal withdrawal syndrome, risk of congenital/perinatal infections through maternal infections, is an important risk factor for neonatal morbidity and mortality.

摘要

引言

孕期药物成瘾的影响在短期和长期内都与多种孕产妇、胎儿和新生儿风险相关。

方法

这是一项在罗马尼亚布加勒斯特“亚历山德雷斯库 - 鲁塞斯库”国家妇幼保健研究所——“波利祖”妇产科医院(高级别妇产医院)进行的回顾性描述性研究,纳入了过去22年(2002 - 2024年)中孕期及孕前使用非法药物的母亲所生的新生儿。

结果

在所研究的时间段内,药物成瘾母亲所生新生儿的发病率稳步上升,尤其是在过去12年。新生儿发病率的特征包括:戒断综合征(61.2%的病例)、通过母体感染导致的先天性/围产期感染风险(58.16%)、早产(43.87%)、出生体重≤2500g(55.10%)、宫内生长受限。

结论

孕期使用非法药物与早产、宫内生长受限、新生儿戒断综合征、通过母体感染导致的先天性/围产期感染风险相关,是新生儿发病和死亡的重要危险因素。

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