• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Is it appropriate to conduct a disproportionality analysis using a spontaneous reporting database to investigate whether drug-related adverse events are dose-dependent?

作者信息

Noguchi Yoshihiro, Tachi Tomoya, Yoshimura Tomoaki

机构信息

Laboratory of Clinical Pharmacy, Gifu Pharmaceutical University, Gifu, Japan.

Department of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Aichi, Japan.

出版信息

Front Pharmacol. 2025 Aug 29;16:1563524. doi: 10.3389/fphar.2025.1563524. eCollection 2025.

DOI:10.3389/fphar.2025.1563524
PMID:40949121
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12425998/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb7f/12425998/036f7f5b4d2d/fphar-16-1563524-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb7f/12425998/849d1db62406/fphar-16-1563524-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb7f/12425998/036f7f5b4d2d/fphar-16-1563524-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb7f/12425998/849d1db62406/fphar-16-1563524-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb7f/12425998/036f7f5b4d2d/fphar-16-1563524-g002.jpg

相似文献

1
Is it appropriate to conduct a disproportionality analysis using a spontaneous reporting database to investigate whether drug-related adverse events are dose-dependent?使用自发报告数据库进行不成比例分析以调查药物相关不良事件是否与剂量相关是否合适？
Front Pharmacol. 2025 Aug 29;16:1563524. doi: 10.3389/fphar.2025.1563524. eCollection 2025.
2
Ductus Arteriosus Variability Linked to Maternal Drug Exposure: Assessment of the USFDA Adverse Event Reporting System using Disproportionality Analysis.动脉导管变异与母体药物暴露相关：使用不成比例分析评估美国食品药品监督管理局不良事件报告系统
Curr Vasc Pharmacol. 2025 Aug 13. doi: 10.2174/0115701611369928250804093531.
3
Stratified analysis of the association between anti-obesity medications and digestive adverse events: a real-world study based on the FDA adverse event reporting system database.基于 FDA 不良事件报告系统数据库的真实世界研究：抗肥胖药物与消化道不良事件关联性的分层分析。
BMC Pharmacol Toxicol. 2024 Sep 12;25(1):64. doi: 10.1186/s40360-024-00789-9.
4
The Role of Disproportionality Analysis of Pharmacovigilance Databases in Safety Regulatory Actions: a Systematic Review.药物警戒数据库的不均衡性分析在安全监管行动中的作用：一项系统评价
Curr Drug Saf. 2015;10(3):234-50. doi: 10.2174/1574886310666150729112903.
5
Cisplatin-Based Combinations-Associated Vasculopathy - A Disproportionality Analysis of Real-World Pharmacovigilance Data.基于顺铂的联合用药相关性血管病变——真实世界药物警戒数据的不成比例性分析
Curr Drug Saf. 2025 Aug 8. doi: 10.2174/0115748863312388240829190436.
6
Abortion adverse events associated with adalimumab, etanercept, ustekinumab, and dupilumab during pregnancy: A pharmacovigilance study based on FDA adverse event reporting system.妊娠期间与阿达木单抗、依那西普、乌司奴单抗和度普利尤单抗相关的流产不良事件：一项基于美国食品药品监督管理局不良事件报告系统的药物警戒研究。
Drug Discov Ther. 2025 Jul 4;19(3):160-173. doi: 10.5582/ddt.2025.01043. Epub 2025 Jun 29.
7
Comparison of Adverse Events in Pregnant Persons Receiving COVID-19 and Influenza Vaccines: A Disproportionality Analysis Using Combined Data from US VAERS and EudraVigilance Spontaneous Report Databases.接种新冠疫苗与流感疫苗的孕妇不良事件比较：一项使用美国疫苗不良事件报告系统（VAERS）和欧洲药物警戒自发报告数据库综合数据的不成比例分析
Drug Saf. 2025 Jun 10. doi: 10.1007/s40264-025-01561-6.
8
Analysis of Adverse Drug Reactions of Clofazimine Reported in the FDA Adverse Event Reporting System from 2004 to 2025 Q1.2004年至2025年第一季度美国食品药品监督管理局不良事件报告系统中报告的氯法齐明药物不良反应分析。
Infect Dis Ther. 2025 Sep 13. doi: 10.1007/s40121-025-01224-0.
9
Safety evaluation of irinotecan: a real-world disproportionality analysis using FAERS and JADER databases during the time period 2004-2024.伊立替康的安全性评估：2004年至2024年期间使用FAERS和JADER数据库进行的真实世界不成比例性分析。
Front Pharmacol. 2025 Jun 9;16:1516449. doi: 10.3389/fphar.2025.1516449. eCollection 2025.
10
Convalescent plasma for people with COVID-19: a living systematic review.COVID-19 患者恢复期血浆治疗：一项实时系统评价。
Cochrane Database Syst Rev. 2023 Feb 1;2(2):CD013600. doi: 10.1002/14651858.CD013600.pub5.

本文引用的文献

1
Dose-dependent pancreatitis risk associated with GLP-1 agonists.与胰高血糖素样肽-1受体激动剂相关的剂量依赖性胰腺炎风险。
J Diabetes Metab Disord. 2025 Jan 2;24(1):33. doi: 10.1007/s40200-024-01552-x. eCollection 2025 Jun.
2
Is ibrutinib-related atrial fibrillation dose dependent? Insights from an individual case level analysis of the World Health Organization pharmacovigilance database.伊布替尼相关房颤与剂量有关吗？来自世界卫生组织药物警戒数据库的个体病例水平分析的见解。
Leukemia. 2024 Dec;38(12):2628-2635. doi: 10.1038/s41375-024-02413-5. Epub 2024 Sep 19.
3
Caveats of Covariate Adjustment in Disproportionality Analysis for Best Practices.
最佳实践中不成比例分析协变量调整的注意事项。
Drug Saf. 2025 Jan;48(1):1-5. doi: 10.1007/s40264-024-01473-x. Epub 2024 Aug 17.
4
The Reporting of a Disproportionality Analysis for Drug Safety Signal Detection Using Individual Case Safety Reports in PharmacoVigilance (READUS-PV): Development and Statement.使用个体病例安全报告在药物警戒中进行药物安全性信号检测的不均衡分析报告：方法学开发与声明。
Drug Saf. 2024 Jun;47(6):575-584. doi: 10.1007/s40264-024-01421-9. Epub 2024 May 7.
5
Detection Algorithms for Simple Two-Group Comparisons Using Spontaneous Reporting Systems.基于自发呈报系统的简单两组比较检测算法。
Drug Saf. 2024 Jun;47(6):535-543. doi: 10.1007/s40264-024-01404-w. Epub 2024 Feb 22.
6
Analysis of clozapine-induced seizures using the Japanese Adverse Drug Event Report database.利用日本不良药物事件报告数据库分析氯氮平引起的癫痫发作。
PLoS One. 2023 Jun 12;18(6):e0287122. doi: 10.1371/journal.pone.0287122. eCollection 2023.
7
A Comparative Safety Analysis of Medicines Based on the UK Pharmacovigilance and General Practice Prescribing Data in England.基于英国药物警戒和英格兰一般实践处方数据的药品比较安全性分析。
In Vivo. 2022 Mar-Apr;36(2):780-800. doi: 10.21873/invivo.12765.
8
Verification of the "Upward Variation in the Reporting Odds Ratio Scores" to Detect the Signals of Drug-Drug Interactions.验证“报告比值比分数的上升变化”以检测药物相互作用信号
Pharmaceutics. 2021 Sep 22;13(10):1531. doi: 10.3390/pharmaceutics13101531.
9
Leveraging Case Narratives to Enhance Patient Age Ascertainment from Adverse Event Reports.利用病例叙述来增强从不良事件报告中确定患者年龄的能力。
Pharmaceut Med. 2021 Sep;35(5):307-316. doi: 10.1007/s40290-021-00398-5. Epub 2021 Sep 2.
10
Detection algorithms and attentive points of safety signal using spontaneous reporting systems as a clinical data source.基于自发报告系统的临床数据来源的安全信号检测算法和关注要点。
Brief Bioinform. 2021 Nov 5;22(6). doi: 10.1093/bib/bbab347.