Naser-Tavakolian Aurash, Lee Ziho
Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Transl Androl Urol. 2025 Aug 30;14(8):2405-2418. doi: 10.21037/tau-24-503. Epub 2025 Jul 24.
Vesicourethral anastomotic stenosis (VUAS), a sequela of radical prostatectomy, is among the most complex conditions managed by reconstructive urologists. As a distinct entity from bladder neck contracture, VUAS can be managed endoscopically or with reconstruction. There is a paucity of higher-level evidence and head-to-head comparisons between VUAS management options. Interpretation of existing studies is further complicated by variations in diagnostic staging of VUAS, definitions of recurrent VUAS, and criteria for post-procedural success. Multiple endoscopic approaches are available including dilation, transurethral incision, transurethral resection, intralesional injections, and endoscopic urethroplasty. Classically, reconstruction for VUAS is offered after a single failed attempt at endoscopic management. Reconstructive options include transperineal reconstruction, open abdominopelvic reconstruction, and robotic-assisted surgical techniques. In recent years, several advances in reconstruction have developed into minimally invasive techniques using multi- and single-port robotics. Early outcomes of robotic reconstructive surgery demonstrate excellent rates of treatment success and, compared to open approaches, notably lower rates of urinary incontinence. Both endoscopic and surgical treatment of VUAS present significant risks of morbidity including the potential need for urinary diversion, therefore appropriate patient counseling and shared decision-making are critical prior to urologic intervention.
膀胱尿道吻合口狭窄(VUAS)是根治性前列腺切除术后的一种后遗症,是重建泌尿外科医生所处理的最复杂病症之一。作为一种有别于膀胱颈挛缩的独特病症,VUAS可通过内镜治疗或重建手术进行处理。目前缺乏关于VUAS治疗方案的高级别证据以及直接比较。VUAS诊断分期的差异、复发性VUAS的定义以及术后成功标准,使得对现有研究的解读更加复杂。内镜治疗方法有多种,包括扩张、经尿道切开、经尿道切除、病灶内注射以及内镜尿道成形术。传统上,在单次内镜治疗尝试失败后才会考虑进行VUAS重建手术。重建手术方案包括经会阴重建、开放腹盆腔重建以及机器人辅助手术技术。近年来,重建手术取得了多项进展,发展出了使用多端口和单端口机器人技术的微创技术。机器人重建手术的早期结果显示治疗成功率很高,而且与开放手术相比,尿失禁发生率显著降低。VUAS的内镜治疗和手术治疗均存在显著的发病风险,包括可能需要进行尿流改道,因此在泌尿外科干预之前,对患者进行适当的咨询并共同做出决策至关重要。