Akhila T R, Ganesh T N, Azimah A, Kok M K, Salleh A
MVSc in Veterinary Surgery, KM Global Animal Hospital, 5 Jalan Industri Batu Caves, 1/1, Taman Perindustrian Batu Caves, Selangor, Malaysia.
Ph.D. in Veterinary Surgery, KM Global Animal Hospital, 5 Jalan Industri Batu Caves, 1/1, Taman Perindustrian Batu Caves, Selangor, Malaysia.
Iran J Vet Res. 2025;26(1):88-93. doi: 10.22099/ijvr.2025.50585.7473.
Uterine leiomyosarcoma is a malignant neoplasm arising from leiomyocytes in the uterus.
A 12-year-old mixed-breed intact female dog was presented with vaginal bleeding for the past 2 weeks. Abdominal ultrasonography revealed a mixed echogenic mass in the uterus, and right lateral abdominal radiography showed a large mid-abdominal mass. Exploratory celiotomy was performed, revealing a solid mass in the entire uterine body and both uterine horns. Ovariohysterectomy was performed and the uterine mass sample was microscopically examined.
FINDINGS/TREATMENT AND OUTCOME: The mass was composed of a dense proliferation of neoplastic cells that display two morphologic features; spindloid and epithelioid appearances. Additionally, chondroid-like matrix was noted. Both components were negative for cytokeratin AE1/AE3, and strongly positive for vimentin. The spindloid component was strongly positive for α-SMA, while the epithelioid-like component was moderately positive for alpha-smooth muscle actin. These findings are suggestive of a leiomyosarcoma. Although the recovery immediately following surgery was smooth and without complications, the dog's condition worsened over the following month, ultimately leading to euthanasia.
This report describes the histopathologic features and clinical outcome of an unusual variant of uterine leiomyosarcoma in a dog.
子宫平滑肌肉瘤是一种起源于子宫平滑肌细胞的恶性肿瘤。
一只12岁的杂种未绝育雌性犬，过去两周出现阴道出血。腹部超声检查发现子宫内有一个混合回声团块，右侧腹部X线摄影显示中腹部有一个大肿块。进行了剖腹探查术，发现整个子宫体和双侧子宫角有一个实性肿块。实施了卵巢子宫切除术，并对子宫肿块样本进行了显微镜检查。
检查结果/治疗及结果：肿块由密集增生的肿瘤细胞组成，呈现两种形态特征；梭形和上皮样外观。此外，还发现了软骨样基质。两种成分的细胞角蛋白AE1/AE3均为阴性，波形蛋白均为强阳性。梭形成分α-SMA强阳性，而上皮样成分α-平滑肌肌动蛋白中度阳性。这些结果提示为平滑肌肉瘤。尽管术后立即恢复顺利且无并发症，但该犬的病情在接下来的一个月内恶化，最终导致安乐死。
本报告描述了一只犬子宫平滑肌肉瘤不寻常变体的组织病理学特征和临床结果。
