Koncagül S, Kasakolu A, Yıldırır M, Ünay E, Koyun H, Karakoyunlu I, Yiğit O, Şen A Ö
Department of Animal Science, Faculty of Agriculture, Ankara University, Ankara, Turkey.
Ph.D. Student in Animal Breeding and Genetics, Department of Animal Science, Graduate School of Natural and Applied Sciences, Ankara University, Ankara, Turkey.
Iran J Vet Res. 2025;26(1):59-67. doi: 10.22099/ijvr.2025.50205.7407.
Conformation traits (CNTs) are part of the selection goals that significantly affect cow economic efficiency, health, welfare, and productive life in the dairy industry.
This study focused on a genome-wide association study (GWAS) and genetic parameters estimation for 21 CNTs, including udder, leg-foot, body, type, and final classification traits in the Turkish Holstein (THol) dairy cattle population.
A restricted maximum likelihood with a univariate model including the fixed effects of herd-year-season and days in milk was used. The total dataset consisted of CNTs records and Affymetrix BovineSNP54K data for 3,008 THol cows that calved from 2019 to 2022. The gene ontology and Kyoto Encyclopedia of genes and genome pathway databases were used to assign genes to functional categories. The biological pathways were performed in BioMart databases.
The heritability of these 21 CNTs ranged from 0.01 (udder index) to 0.133 (udder depth). A total of 16 significant single nucleotide polymorphisms (SNP) associated with 13 CNTs was identified. Significant SNP overlap in the candidate genes, which include , , and , have potential for researchers and breeders for CNTs in cattle breeding.
These results provide valuable knowledge and contribute to the elucidation of the genetic factors responsible for conformation traits in dairy cattle populations.
体型性状（CNTs）是选择目标的一部分，对奶牛养殖业的经济效率、健康、福利和生产寿命有显著影响。
本研究聚焦于对21种CNTs进行全基因组关联研究（GWAS）和遗传参数估计，这些性状包括土耳其荷斯坦（THol）奶牛群体的乳房、腿足、体型、类型和最终分类性状。
使用包含畜群-年份-季节和产奶天数固定效应的单变量模型的限制最大似然法。总数据集由2019年至2022年产犊的3008头THol奶牛的CNTs记录和Affymetrix BovineSNP54K数据组成。利用基因本体论和京都基因与基因组百科全书通路数据库将基因分配到功能类别。生物学通路在BioMart数据库中进行。
这21种CNTs的遗传力范围为0.01（乳房指数）至0.133（乳房深度）。共鉴定出与13种CNTs相关的16个显著单核苷酸多态性（SNP）。候选基因中的显著SNP重叠，包括 、 和 ，对牛育种中CNTs的研究人员和育种者具有潜在意义。
这些结果提供了有价值的知识，并有助于阐明奶牛群体中体型性状的遗传因素。
