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The surgical perspective on CAIRO5 and beyond: all patients with colorectal liver metastases should be evaluated by a liver surgeon, but what defines resectability?

作者信息

Wu Victoria S, Ocuin Lee M

机构信息

Department of Surgery, Brigham and Women's Hospital, Boston, MA, USA.

Division of Surgical Oncology, Jefferson Health-Lehigh Valley Topper Cancer Institute, Allentown, PA, USA.

出版信息

J Gastrointest Oncol. 2025 Aug 30;16(4):1768-1772. doi: 10.21037/jgo-2025-291. Epub 2025 Aug 7.

DOI:10.21037/jgo-2025-291
PMID:40950334
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12432956/
Abstract
摘要

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本文引用的文献

1
Parenchymal-sparing non-anatomic resection vs. classic anatomic resection in colorectal cancer liver metastases.结直肠癌肝转移中保留实质的非解剖性切除与经典解剖性切除的比较
Ann Hepatobiliary Pancreat Surg. 2025 May 31;29(2):121-126. doi: 10.14701/ahbps.24-151. Epub 2025 Feb 18.
2
Thermal ablation versus surgical resection of small-size colorectal liver metastases (COLLISION): an international, randomised, controlled, phase 3 non-inferiority trial.小尺寸结直肠癌肝转移灶的热消融与手术切除对比研究（COLLISION）：一项国际、随机、对照、3期非劣效性试验
Lancet Oncol. 2025 Feb;26(2):187-199. doi: 10.1016/S1470-2045(24)00660-0. Epub 2025 Jan 20.
3
First-Line Systemic Treatment for Initially Unresectable Colorectal Liver Metastases: Post Hoc Analysis of the CAIRO5 Randomized Clinical Trial.
初治不可切除结直肠癌肝转移的一线全身治疗：CAIRO5随机临床试验的事后分析
JAMA Oncol. 2025 Jan 1;11(1):36-45. doi: 10.1001/jamaoncol.2024.5174.
4
Liver transplantation plus chemotherapy versus chemotherapy alone in patients with permanently unresectable colorectal liver metastases (TransMet): results from a multicentre, open-label, prospective, randomised controlled trial.肝移植联合化疗与单纯化疗治疗无法根治性切除的结直肠癌肝转移患者（TransMet）：一项多中心、开放标签、前瞻性、随机对照临床试验的结果。
Lancet. 2024 Sep 21;404(10458):1107-1118. doi: 10.1016/S0140-6736(24)01595-2.
5
Outcomes of Hepatic Artery-Based Therapies and Systemic Multiagent Chemotherapy in Unresectable Colorectal Liver Metastases: A Systematic Review and Meta-analysis.肝动脉介入治疗与全身多药化疗用于不可切除结直肠癌肝转移的疗效：一项系统评价与Meta分析
Ann Surg Oncol. 2024 Jul;31(7):4413-4426. doi: 10.1245/s10434-024-15187-y. Epub 2024 Mar 19.
6
First-line systemic treatment strategies in patients with initially unresectable colorectal cancer liver metastases (CAIRO5): an open-label, multicentre, randomised, controlled, phase 3 study from the Dutch Colorectal Cancer Group.初治不可切除的结直肠癌肝转移患者的一线全身治疗策略（CAIRO5）：一项来自荷兰结直肠癌研究组的开放标签、多中心、随机、对照3期研究
Lancet Oncol. 2023 Jul;24(7):757-771. doi: 10.1016/S1470-2045(23)00219-X. Epub 2023 Jun 14.
7
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J Gastrointest Surg. 2022 Mar;26(3):594-601. doi: 10.1007/s11605-021-05122-x. Epub 2021 Sep 10.
8
Failure to Cure Patients with Colorectal Liver Metastases: The Impact of the Liver Surgeon.未能治愈结直肠癌肝转移患者：肝外科医生的影响。
Ann Surg Oncol. 2021 Nov;28(12):7698-7706. doi: 10.1245/s10434-021-10030-0. Epub 2021 Apr 30.
9
Questioning Why More Patients With Colorectal Liver Metastases Are Not Referred for Metastasectomy.质疑为何更多结直肠癌肝转移患者未被转诊接受肝转移灶切除术。
JAMA Surg. 2020 Oct 1;155(10):909-910. doi: 10.1001/jamasurg.2020.1460.
10
Actual 10-year survival after hepatic resection of colorectal liver metastases: what factors preclude cure?结直肠肝转移灶切除术后的 10 年实际生存率：哪些因素妨碍治愈？
Surgery. 2018 Jun;163(6):1238-1244. doi: 10.1016/j.surg.2018.01.004. Epub 2018 Feb 15.