• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

主要穹窿蛋白（MVP）介导的脂肪细胞对三阴性乳腺癌化疗敏感性的研究。

Investigation into the sensitivity of adipocytes mediated by the major vault protein (MVP) to chemotherapy for triple-negative breast cancer.

作者信息

Qin Lianjin, Fei Ruofan, Wang Wenjuan, He Qingjian

机构信息

Department of Thyroid and Breast Surgery, First Affiliated Hospital of Huzhou University, Huzhou, China.

Cardiovascular Diagnosis and Treatment Center, First Affiliated Hospital of Huzhou University, Huzhou, China.

出版信息

Transl Cancer Res. 2025 Aug 31;14(8):5109-5126. doi: 10.21037/tcr-2025-1175. Epub 2025 Aug 28.

DOI:10.21037/tcr-2025-1175
PMID:40950669
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12432768/
Abstract

BACKGROUND

Chemotherapy is an important therapeutic method for treating triple-negative breast cancer (TNBC), and docetaxel is the most commonly used chemotherapy drug for TNBC. Fat cells may increase the aggressiveness of TNBC and reduce the therapeutic effect of docetaxel. This research aimed to examine the mechanisms underlying the reduced chemosensitivity of TNBC to docetaxel.

METHODS

Cell migration and invasion experiments revealed that breast cancer cells cocultured with mature adipocytes had increased invasive and migratory capabilities, and decreased sensitivity to docetaxel chemotherapy. Immunofluorescence and Western blot analyses revealed the significant upregulation of major vault protein (MVP) expression in the cocultured breast cancer cells.

RESULTS

Our findings indicated that docetaxel effectively inhibited the proliferation, migration, and invasion of the MDA-MB231 cells. The optimal therapeutic concentration for the MDA-MB231 cells was 1,000 nM, and the optimal treatment duration was 48 hours.

CONCLUSIONS

The level of MVP expression appears to influence the chemosensitivity of breast cancer cells to docetaxel. Notably, our results suggest that cocultured breast cancer cells may modulate MVP expression via the Notch1 signaling pathway. Overall, this study provides evidence that adipocytes could influence the chemosensitivity of TNBC cells to docetaxel via MVP expression.

摘要

背景

化疗是治疗三阴性乳腺癌（TNBC）的重要治疗方法，多西他赛是TNBC最常用的化疗药物。脂肪细胞可能会增加TNBC的侵袭性并降低多西他赛的治疗效果。本研究旨在探讨TNBC对多西他赛化疗敏感性降低的潜在机制。

方法

细胞迁移和侵袭实验表明，与成熟脂肪细胞共培养的乳腺癌细胞具有增强的侵袭和迁移能力，并且对多西他赛化疗的敏感性降低。免疫荧光和蛋白质印迹分析显示，共培养的乳腺癌细胞中主要穹窿蛋白（MVP）表达显著上调。

结果

我们的研究结果表明，多西他赛有效地抑制了MDA-MB231细胞的增殖、迁移和侵袭。MDA-MB231细胞的最佳治疗浓度为1000 nM，最佳治疗持续时间为48小时。

结论

MVP表达水平似乎影响乳腺癌细胞对多西他赛的化疗敏感性。值得注意的是，我们的结果表明，共培养的乳腺癌细胞可能通过Notch1信号通路调节MVP表达。总体而言，本研究提供了证据表明脂肪细胞可通过MVP表达影响TNBC细胞对多西他赛的化疗敏感性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/571f/12432768/24b5f0f353fe/tcr-14-08-5109-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/571f/12432768/cb27c9121e66/tcr-14-08-5109-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/571f/12432768/737a37a854ce/tcr-14-08-5109-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/571f/12432768/469484034bd4/tcr-14-08-5109-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/571f/12432768/0cd03c506d0a/tcr-14-08-5109-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/571f/12432768/50b16d0d39e7/tcr-14-08-5109-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/571f/12432768/fab94abcacfc/tcr-14-08-5109-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/571f/12432768/999ad5ab5dee/tcr-14-08-5109-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/571f/12432768/24b5f0f353fe/tcr-14-08-5109-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/571f/12432768/cb27c9121e66/tcr-14-08-5109-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/571f/12432768/737a37a854ce/tcr-14-08-5109-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/571f/12432768/469484034bd4/tcr-14-08-5109-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/571f/12432768/0cd03c506d0a/tcr-14-08-5109-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/571f/12432768/50b16d0d39e7/tcr-14-08-5109-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/571f/12432768/fab94abcacfc/tcr-14-08-5109-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/571f/12432768/999ad5ab5dee/tcr-14-08-5109-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/571f/12432768/24b5f0f353fe/tcr-14-08-5109-f8.jpg

相似文献

1
Investigation into the sensitivity of adipocytes mediated by the major vault protein (MVP) to chemotherapy for triple-negative breast cancer.主要穹窿蛋白（MVP）介导的脂肪细胞对三阴性乳腺癌化疗敏感性的研究。
Transl Cancer Res. 2025 Aug 31;14(8):5109-5126. doi: 10.21037/tcr-2025-1175. Epub 2025 Aug 28.
2
Metabolic Targeting of Oxidative Phosphorylation Enhances Chemosensitivity in Triple-Negative Breast Cancer via a Synergistic Nanomedicine.通过协同纳米药物对氧化磷酸化进行代谢靶向可增强三阴性乳腺癌的化疗敏感性。
Theranostics. 2025 Jun 23;15(15):7607-7626. doi: 10.7150/thno.116250. eCollection 2025.
3
SNHG14 promotes triple-negative breast cancer cell proliferation, invasion, and chemoresistance by regulating the ERK/MAPK signaling pathway.SNHG14 通过调控 ERK/MAPK 信号通路促进三阴性乳腺癌细胞的增殖、侵袭和化疗耐药性。
IUBMB Life. 2024 Dec;76(12):1295-1308. doi: 10.1002/iub.2910. Epub 2024 Sep 12.
4
A rapid and systematic review of the clinical effectiveness and cost-effectiveness of paclitaxel, docetaxel, gemcitabine and vinorelbine in non-small-cell lung cancer.对紫杉醇、多西他赛、吉西他滨和长春瑞滨在非小细胞肺癌中的临床疗效和成本效益进行的快速系统评价。
Health Technol Assess. 2001;5(32):1-195. doi: 10.3310/hta5320.
5
Mechanism of xihuang pill inhibition of SLC7A11 deubiquitination through downregulation of the OTUB1 to promote ferroptosis in triple-negative breast cancer.西黄丸通过下调OTUB1抑制SLC7A11去泛素化以促进三阴性乳腺癌铁死亡的机制
J Ethnopharmacol. 2025 Aug 20;353(Pt B):120456. doi: 10.1016/j.jep.2025.120456.
6
Mechanistic study on the inhibition of triple-negative breast cancer progression by LncRNA TFAP2A-AS1 through the regulation of miR-6892/PHGDH.LncRNA TFAP2A-AS1通过调控miR-6892/PHGDH抑制三阴性乳腺癌进展的机制研究
Inflamm Res. 2025 Sep 10;74(1):121. doi: 10.1007/s00011-025-02092-7.
7
Platinum-based chemotherapy for early triple-negative breast cancer.含铂化疗治疗早期三阴性乳腺癌。
Cochrane Database Syst Rev. 2023 Sep 8;9(9):CD014805. doi: 10.1002/14651858.CD014805.pub2.
8
Pembrolizumab plus chemotherapy for first-line treatment of advanced triple-negative breast cancer.帕博利珠单抗联合化疗用于晚期三阴性乳腺癌的一线治疗。
Future Oncol. 2024;20(22):1587-1600. doi: 10.2217/fon-2023-0301. Epub 2024 Apr 10.
9
Clinical and Biomarker Findings of Neoadjuvant Pembrolizumab and Carboplatin Plus Docetaxel in Triple-Negative Breast Cancer: NeoPACT Phase 2 Clinical Trial.新辅助帕博利珠单抗联合卡铂加多西他赛治疗三阴性乳腺癌的临床和生物标志物研究：NeoPACT Ⅱ期临床试验。
JAMA Oncol. 2024 Feb 1;10(2):227-235. doi: 10.1001/jamaoncol.2023.5033.
10
Chemotherapy for advanced gastric cancer.晚期胃癌的化疗
Cochrane Database Syst Rev. 2017 Aug 29;8(8):CD004064. doi: 10.1002/14651858.CD004064.pub4.

本文引用的文献

1
MVP-LCN2 axis triggers evasion of ferroptosis to drive hepatocarcinogenesis and sorafenib resistance.MVP-LCN2轴触发铁死亡逃避以驱动肝癌发生和索拉非尼耐药。
Drug Resist Updat. 2025 Jul;81:101246. doi: 10.1016/j.drup.2025.101246. Epub 2025 Apr 17.
2
Adipose-derived stem cell exosomal miR-21-5p enhances angiogenesis in endothelial progenitor cells to promote bone repair via the NOTCH1/DLL4/VEGFA signaling pathway.脂肪来源干细胞外泌体 miR-21-5p 通过 NOTCH1/DLL4/VEGFA 信号通路增强内皮祖细胞中的血管生成，从而促进骨修复。
J Transl Med. 2024 Nov 8;22(1):1009. doi: 10.1186/s12967-024-05806-3.
3
Human adipose and umbilical cord mesenchymal stem cell-derived extracellular vesicles mitigate photoaging via TIMP1/Notch1.
人脂肪和脐带间充质干细胞衍生的细胞外囊泡通过 TIMP1/Notch1 减轻光老化。
Signal Transduct Target Ther. 2024 Oct 30;9(1):294. doi: 10.1038/s41392-024-01993-z.
4
Adipocyte-derived glutathione promotes obesity-related breast cancer by regulating the SCARB2-ARF1-mTORC1 complex.脂肪细胞衍生的谷胱甘肽通过调节SCARB2-ARF1-mTORC1复合物促进肥胖相关的乳腺癌。
Cell Metab. 2025 Mar 4;37(3):692-707.e9. doi: 10.1016/j.cmet.2024.09.013. Epub 2024 Oct 22.
5
1α,25-Dihydroxyvitamin D Downregulates Adipocyte Impact on Breast Cancer Cell Migration and Adipokine Release.1α,25-二羟维生素 D 下调脂肪细胞对乳腺癌细胞迁移和脂肪因子释放的影响。
Nutrients. 2024 Sep 18;16(18):3153. doi: 10.3390/nu16183153.
6
Exosomal fragment enclosed polyamine-salt nano-complex for co-delivery of docetaxel and mir-34a exhibits higher cytotoxicity and apoptosis in breast cancer cells.外泌体包裹多胺盐纳米复合物共递送多西他赛和 mir-34a 可提高乳腺癌细胞的细胞毒性和促凋亡作用。
Sci Rep. 2024 Sep 17;14(1):21669. doi: 10.1038/s41598-024-72226-0.
7
Unraveling the role of Major Vault Protein as a novel immune-related biomarker that promotes the proliferation and migration in pancreatic adenocarcinoma.揭示主要穹窿蛋白作为一种新型免疫相关生物标志物在胰腺腺癌中促进增殖和迁移的作用。
Front Immunol. 2024 Jul 4;15:1399222. doi: 10.3389/fimmu.2024.1399222. eCollection 2024.
8
Notch signaling pathway in cancer: from mechanistic insights to targeted therapies. Notch 信号通路与癌症：从机制研究到靶向治疗。
Signal Transduct Target Ther. 2024 May 27;9(1):128. doi: 10.1038/s41392-024-01828-x.
9
Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.2022 年全球癌症统计数据：全球 185 个国家和地区 36 种癌症的发病率和死亡率全球估计数。
CA Cancer J Clin. 2024 May-Jun;74(3):229-263. doi: 10.3322/caac.21834. Epub 2024 Apr 4.
10
Cancer statistics, 2024.2024年癌症统计数据。
CA Cancer J Clin. 2024 Jan-Feb;74(1):12-49. doi: 10.3322/caac.21820. Epub 2024 Jan 17.