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The COURSE trial and beyond: rethinking chronic obstructive pulmonary disease exacerbation management with biologics.

作者信息

Kashizaki Fumihiro, Chen Hao

机构信息

Department of Respiratory Medicine, Yokohama Minami Kyosai Hospital, Kanagawa, Japan.

出版信息

J Thorac Dis. 2025 Aug 31;17(8):6356-6363. doi: 10.21037/jtd-2025-705. Epub 2025 Aug 27.

DOI:10.21037/jtd-2025-705
PMID:40950879
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12433091/
Abstract
摘要

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本文引用的文献

1
Factors Influencing the Efficacy and Safety of Monoclonal Antibody Biologics in Chronic Obstructive Pulmonary Disease: A Meta-analysis of Randomized Controlled Trials.影响单克隆抗体生物制剂在慢性阻塞性肺疾病中疗效和安全性的因素：一项随机对照试验的荟萃分析
Lung. 2025 Mar 14;203(1):46. doi: 10.1007/s00408-025-00795-6.
2
Mepolizumab to Prevent Exacerbations of COPD with an Eosinophilic Phenotype.美泊利单抗预防嗜酸性粒细胞型慢性阻塞性肺疾病的急性加重
N Engl J Med. 2025 May 1;392(17):1710-1720. doi: 10.1056/NEJMoa2413181.
3
A phase 2a trial of the IL-33 monoclonal antibody tozorakimab in patients with COPD: FRONTIER-4.
一项评估IL-33单克隆抗体托扎单抗治疗慢性阻塞性肺疾病患者的2a期试验：FRONTIER-4。
Eur Respir J. 2025 Jul 14;66(1). doi: 10.1183/13993003.02231-2024. Print 2025 Jul.
4
Biomarkers of inflammation associated with radon exposure in the School Inner-City Asthma Study (SICAS).学校内城哮喘研究（SICAS）中与氡暴露相关的炎症生物标志物。
J Allergy Clin Immunol. 2025 Jun;155(6):1866-1872. doi: 10.1016/j.jaci.2025.01.033. Epub 2025 Feb 7.
5
Dupilumab for chronic obstructive pulmonary disease with type 2 inflammation: a pooled analysis of two phase 3, randomised, double-blind, placebo-controlled trials.度普利尤单抗用于治疗伴有2型炎症的慢性阻塞性肺疾病：两项3期随机双盲安慰剂对照试验的汇总分析
Lancet Respir Med. 2025 Mar;13(3):234-243. doi: 10.1016/S2213-2600(24)00409-0. Epub 2025 Jan 31.
6
TSLP and TSLPr Expression and Localization in the Airways of COPD and Non-COPD Patients.TSLP和TSLPr在慢性阻塞性肺疾病（COPD）和非COPD患者气道中的表达及定位
Eur J Immunol. 2025 Jan;55(1):e202451480. doi: 10.1002/eji.202451480.
7
Efficacy and safety of tezepelumab versus placebo in adults with moderate to very severe chronic obstructive pulmonary disease (COURSE): a randomised, placebo-controlled, phase 2a trial.特泽佩umab对比安慰剂治疗中重度至非常重度慢性阻塞性肺疾病成人患者的疗效和安全性（COURSE）：一项随机、安慰剂对照的2a期试验
Lancet Respir Med. 2025 Jan;13(1):47-58. doi: 10.1016/S2213-2600(24)00324-2. Epub 2024 Dec 6.
8
Real-World and Patient-Reported Outcomes of Dupilumab and Other Biological Drugs for Chronic Obstructive Pulmonary Disease-A Systematic Review.度普利尤单抗及其他生物药物治疗慢性阻塞性肺疾病的真实世界和患者报告结局——一项系统评价
Diagnostics (Basel). 2024 Oct 26;14(21):2390. doi: 10.3390/diagnostics14212390.
9
Clinical effectiveness and safety of dupilumab in patients with chronic obstructive pulmonary disease: A 7-year population-based cohort study.度普利尤单抗治疗慢性阻塞性肺疾病患者的临床疗效和安全性：一项基于人群的7年队列研究。
J Allergy Clin Immunol. 2025 Jan;155(1):219-222.e1. doi: 10.1016/j.jaci.2024.09.019. Epub 2024 Oct 3.
10
Dupilumab for COPD with Blood Eosinophil Evidence of Type 2 Inflammation.针对伴有血液嗜酸性粒细胞证据的 2 型炎症 COPD 患者的度普利尤单抗。
N Engl J Med. 2024 Jun 27;390(24):2274-2283. doi: 10.1056/NEJMoa2401304. Epub 2024 May 20.