使用酰胺质子转移成像评估肾移植功能。
Assessment of renal allograft function using amide proton transfer imaging.
作者信息
Ge Yaping, Du Jian, Cheng Haichao, Wang Wei
机构信息
Graduate School of Dalian Medical University, Dalian, Liaoning, China.
Department of Radiology, The First Affiliated Hospital of Shandong First Medical University, Jinan, Shandong, China.
出版信息
Front Med (Lausanne). 2025 Aug 29;12:1612028. doi: 10.3389/fmed.2025.1612028. eCollection 2025.
OBJECTIVE
This study aimed to investigate the ability of amide proton transfer (APT) imaging to assess the function of transplanted kidneys.
METHODS
Between October 2023 and July 2024, a total of 44 renal allograft recipients were recruited prospectively, who underwent renal APT imaging with a 3.0 T system 2-3 weeks after transplantation. Recipients were divided into two groups according to the estimated glomerular filtration rate (eGFR): group A, eGFR < 60 mL/min/1.73 m; and group B, eGFR ≥60 mL/min/1.73 m. The relationships between cortical and medullary APT values and allograft function were assessed using the Spearman's correlation coefficient. The paired sample -test was used to compare cortical and medullary APT values. APT values in groups A and B were compared using the Student's -test or Mann-Whitney -test. Receiver operating characteristic curves were generated to assess the ability of cortical and medullary APT values to diagnose impaired allograft function.
RESULTS
Two physicians calculated APT values independently and with good agreement, as indicated by an intraclass correlation coefficient > 0.75. The renal cortical and medullary APT values in group A (2.61% ± 0.51% and 2.11% ± 0.37%, respectively) were significantly higher than those in group B (1.77% ± 0.13% and 1.79% ± 0.29%, respectively) ( < 0.05). APT values in the renal cortex and medulla were negatively correlated with eGFR ( = -0.8551 and = -0.5163, respectively; < 0.01). In group A, cortical APT values were higher than medullary APT values ( < 0.05). Cortical and medullary APT values demonstrated a good ability to diagnose impaired renal allograft function. In group A, mean cortical APT values were higher in patients whose renal function did not recover (3.10% ± 0.54%) than in those with stable allograft function 6 months after transplantation (2.50% ± 0.44%) ( < 0.05).
CONCLUSION
APT imaging is a promising technique for non-invasive functional assessment of renal allografts.
目的
本研究旨在探讨酰胺质子转移（APT）成像评估移植肾肾功能的能力。
方法
2023年10月至2024年7月，前瞻性招募了44例肾移植受者，在移植后2 - 3周用3.0T系统对其进行肾脏APT成像。根据估计肾小球滤过率（eGFR）将受者分为两组：A组，eGFR < 60 mL/min/1.73 m²；B组，eGFR≥60 mL/min/1.73 m²。采用Spearman相关系数评估皮质和髓质APT值与移植肾功能之间的关系。采用配对样本t检验比较皮质和髓质APT值。A组和B组的APT值采用Student's t检验或Mann-Whitney U检验进行比较。绘制受试者工作特征曲线以评估皮质和髓质APT值诊断移植肾功能受损的能力。
结果
两名医生独立计算APT值，组内相关系数>0.75，表明一致性良好。A组肾皮质和髓质的APT值（分别为2.61%±0.51%和2.11%±0.37%）显著高于B组（分别为1.77%±0.13%和1.79%±0.29%）（P<0.05）。肾皮质和髓质的APT值与eGFR呈负相关（分别为r = -0.8551和r = -0.5163；P<0.01）。在A组中，皮质APT值高于髓质APT值（P<0.05）。皮质和髓质APT值对诊断移植肾功能受损具有良好的能力。在A组中，肾功能未恢复的患者平均皮质APT值（3.10%±0.54%）高于移植后6个月移植肾功能稳定的患者（2.50%±0.44%）（P<0.05）。
结论
APT成像是一种很有前景的用于移植肾无创功能评估的技术。
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