[大鼠坐骨神经反复局部冷冻后再生有髓神经纤维数量及大小的变化]
[Variation in the number and size of myelinated nerve fibers regenerated after repeated localized freezing of the sciatic nerve of rats].
作者信息
Mira J C, Fessard M A
出版信息
C R Acad Hebd Seances Acad Sci D. 1977 Jun 20;284(23):2357-60.
The number and size of myelinated fibres have been determined in the nerve to medial head of the gastrocnemius muscle of Rats in which the sciatic nerve had been frozen locally 1 to 5 times at monthly intervals. The contralateral nerve was used as a control. When the measurements were made one month after the last freezing, the number of fibres increased progressively until the 3rd freezing, reaching about 220% of the normal value. No higher values were observed after 4 or 5 freezings. The mean diameter of fibres decreased with the number of operations. When the measurements were made 3, 6, 12 or 18 months after the 3rd freezing, the number of fibres decreased by about 30% between the 1st and the 3rd month and then stabilized. The mean diameter of fibres increased progressively. However, at the 18th month, the size of the myelinated fibres had not reached the normal value.
已测定了大鼠腓肠肌内侧头肌神经中有髓纤维的数量和大小，这些大鼠的坐骨神经已每隔一个月局部冷冻1至5次。对侧神经用作对照。在最后一次冷冻后一个月进行测量时，纤维数量逐渐增加，直至第3次冷冻时达到正常值的约220%。在第4次或第5次冷冻后未观察到更高的值。纤维的平均直径随手术次数的增加而减小。在第3次冷冻后3、6、12或18个月进行测量时，纤维数量在第1个月至第3个月之间减少了约30%，然后稳定下来。纤维的平均直径逐渐增加。然而，在第18个月时，有髓纤维的大小尚未达到正常值。
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