Changes in serum interleukin-6 (IL-6) and C-reactive protein (CRP), PCT after early resuscitation in patients with severe acute pancreatitis.

BACKGROUND

This study investigated the effects of different early resuscitation fluid replenishment rates (FRRs) on inflammation (serum interleukin-6 (IL-6) and C-reactive protein (CRP), PCT and complications in patients with severe acute pancreatitis (SAP).

METHODS

Sixty-six patients with SAP were studied. According to the ratio of total fluid replenishment 24 h after admission to 72 h (FRR), the patients were rolled into a low FRR group (Low group), a moderate FRR group (Moderate group), and a high FRR group (High group), with 22 cases in each. Serum-related indexes, APACHE II score, HCT, systemic inflammatory response syndrome (SIRS) duration, length of hospital stay (LOS), and complication rate (CR) were determined and compared.

RESULTS

The results suggested that ALT, AST, SCr, BUN, TBil, APACHE II, scores and HCT in the Moderate group were the lowest (P< 0.05), while those in the High group were the highest (P<0.05). After the patients were treated for 72 h, the IL-6, CRP and PCT in the Low and High groups were higher than those in the Moderate groups, exhibiting differences with P<0.05 and P<0.01, respectively. The SIRS duration and LOS in the Low and High groups were longer. They presented differences with P<0.05 and P<0.01 to the Moderate group, respectively. The rates of MODS, mechanical ventilation, pancreatic necrosis infection, and death in the Moderate group were the lowest (P<0.05).

CONCLUSIONS

the moderate FRR could effectively alleviate the inflammatory response of patients with SAP shorten the treatment time, and reduce the CR.