Rack Daniel George, Wadia Toranj, Wacher Joseph
Paediatrics, Barts Health NHS Trust, London, UK
Imperial College Healthcare NHS Trust, London, UK.
BMJ Case Rep. 2025 Sep 14;18(9):e266867. doi: 10.1136/bcr-2025-266867.
A COVID-19-positive baby with acute respiratory failure and a working diagnosis of bronchiolitis deteriorated rapidly despite usual resuscitative measures. Respiratory acidosis and oxygenation improved with invasive ventilation; however, the patient became progressively hypotensive and showed a poor response to vasopressors. Bedside ultrasound showed right heart dilatation, troponin was raised, and the ECG had ischaemic changes. Echocardiography diagnosed anomalous aortic origin of the right pulmonary artery (RPA), with continuous left-to-right shunt and holodiastolic flow reversal in the abdominal aorta. This raised suspicion of a coronary steal phenomenon, explaining deterioration in response to typical resuscitation. An oxygen saturation (SpO2) target of 80-88% and permissive hypercapnia helped restore balanced circulations and improve coronary perfusion. He ultimately underwent a complete surgical repair with good recovery. We discuss opportunities for earlier recognition of cardiac differential diagnoses in a neonate with respiratory failure, including the use of bedside ultrasound, which is of interest to paediatric generalists, intensivists and emergency practitioners.
一名新冠病毒检测呈阳性、患有急性呼吸衰竭且初步诊断为细支气管炎的婴儿,尽管采取了常规复苏措施,病情仍迅速恶化。有创通气使呼吸性酸中毒和氧合情况得到改善;然而,患者血压逐渐降低,对血管加压药反应不佳。床旁超声显示右心扩张,肌钙蛋白升高,心电图有缺血性改变。超声心动图诊断为右肺动脉异常起源于主动脉,存在持续的左向右分流以及腹主动脉全舒张期血流逆转。这引发了对冠状动脉窃血现象的怀疑,解释了对典型复苏措施反应不佳的原因。将氧饱和度(SpO₂)目标设定为80 - 88%以及允许性高碳酸血症有助于恢复循环平衡并改善冠状动脉灌注。他最终接受了完整的手术修复,恢复良好。我们讨论了在患有呼吸衰竭的新生儿中更早识别心脏鉴别诊断的机会,包括床旁超声的应用,这对儿科全科医生、重症监护医生和急诊医生都具有重要意义。