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青少年根管囊肿治疗的协同方法:利用富血小板纤维蛋白、脱矿骨基质异种移植物和I型胶原可吸收膜实现最佳愈合

Synergistic Approach to Radicular Cyst Management in an Adolescent: Utilizing Platelet-Rich Fibrin, Demineralized Bone Matrix Xenograft, and Type I Collagen Resorbable Membrane for Optimal Healing.

作者信息

Mishra Rohit, Pradhan Debapriya, Tiwari Saurabh, Choubey Varsha, Saini Nikita

机构信息

Department of Periodontics, Hitkarini Dental College and Hospital, Jabalpur, IND.

Department of Pedodontics and Preventive Dentistry, Hitkarini Dental College and Hospital, Jabalpur, IND.

出版信息

Cureus. 2025 Aug 14;17(8):e90127. doi: 10.7759/cureus.90127. eCollection 2025 Aug.

DOI:10.7759/cureus.90127
PMID:40955243
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12433571/
Abstract

Dentoalveolar injuries can lead to complications like pulpal necrosis, apical periodontitis, and usually radicular cysts, which are common inflammatory odontogenic cysts often triggered by trauma or infection. Radicular cysts are typically asymptomatic but may cause slow, noticeable swelling. This case report details the surgical management of the same in the periapical region of a maxillary incisor in a 12-year-old female patient. The approach included root canal therapy followed by periapical surgery. The cystic lesion was surgically enucleated, and a combination of platelet-rich fibrin (PRF) and demineralized bone matrix (DMBM) xenograft was applied to enhance healing, alongside a type I collagen resorbable membrane. Follow-up evaluations showed the patient was asymptomatic, with significant periapical healing and almost complete bone regeneration observed on radiographs.

摘要

牙槽损伤可导致诸如牙髓坏死、根尖周炎等并发症,通常还会引发根囊肿,根囊肿是常见的炎性牙源性囊肿,常由创伤或感染引发。根囊肿通常无症状,但可能会导致缓慢、明显的肿胀。本病例报告详细介绍了一名12岁女性患者上颌切牙根尖区根囊肿的手术治疗。治疗方法包括根管治疗,随后进行根尖手术。通过手术摘除囊性病变,并应用富血小板纤维蛋白(PRF)和脱矿骨基质(DMBM)异种移植物的组合,同时使用I型胶原可吸收膜来促进愈合。随访评估显示患者无症状,根尖愈合良好,X线片显示几乎完全骨再生。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da13/12433571/2d5bce08451a/cureus-0017-00000090127-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da13/12433571/feba84ccd93e/cureus-0017-00000090127-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da13/12433571/49062bdd909a/cureus-0017-00000090127-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da13/12433571/2d5bce08451a/cureus-0017-00000090127-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da13/12433571/feba84ccd93e/cureus-0017-00000090127-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da13/12433571/49062bdd909a/cureus-0017-00000090127-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da13/12433571/2d5bce08451a/cureus-0017-00000090127-i04.jpg

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Synergistic Approach to Radicular Cyst Management in an Adolescent: Utilizing Platelet-Rich Fibrin, Demineralized Bone Matrix Xenograft, and Type I Collagen Resorbable Membrane for Optimal Healing.青少年根管囊肿治疗的协同方法:利用富血小板纤维蛋白、脱矿骨基质异种移植物和I型胶原可吸收膜实现最佳愈合
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本文引用的文献

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Microsurgical management of radicular cyst using guided tissue regeneration technique: A case report.使用引导组织再生技术对根端囊肿进行显微外科治疗:一例报告。
World J Clin Cases. 2024 Mar 6;12(7):1346-1355. doi: 10.12998/wjcc.v12.i7.1346.
2
Platelet rich fibrin is not a barrier membrane! Or is it?富血小板纤维蛋白不是屏障膜!或者它是吗?
World J Clin Cases. 2023 Apr 16;11(11):2396-2404. doi: 10.12998/wjcc.v11.i11.2396.
3
Surgical Management of Radicular Cyst With the Application of a Natural Platelet Concentrate: A Case Report.
应用天然血小板浓缩物治疗根端囊肿的手术管理:病例报告
Cureus. 2023 Jan 20;15(1):e33992. doi: 10.7759/cureus.33992. eCollection 2023 Jan.
4
Preserving the vitality of teeth adjacent to a large radicular cyst in periapical microsurgery: a case report with 4-year follow-up.根尖周显微手术中保留大根侧囊肿邻牙活力:附 4 年随访的 1 例报告。
BMC Oral Health. 2021 Aug 3;21(1):382. doi: 10.1186/s12903-021-01738-2.
5
Management of Radicular Cyst Using Platelet-Rich Fibrin & Iliac Bone Graft - A Case Report.使用富血小板纤维蛋白和髂骨移植治疗根端囊肿——病例报告
J Clin Diagn Res. 2015 Jun;9(6):ZD34-6. doi: 10.7860/JCDR/2015/13368.6136. Epub 2015 Jun 1.
6
Management of large radicular cyst by conservative surgical approach: a case report.保守手术方法治疗大型根端囊肿:一例报告
J Clin Diagn Res. 2014 Feb;8(2):239-41. doi: 10.7860/JCDR/2014/5763.4069. Epub 2014 Feb 3.
7
Platelet-Rich fibrin: A second generation platelet concentrate and a new friend of oral and maxillofacial surgeons.富血小板纤维蛋白:第二代血小板浓缩物及口腔颌面外科医生的新帮手。
Ann Maxillofac Surg. 2011 Jan;1(1):53-7. doi: 10.4103/2231-0746.83158.
8
Clinical evaluation of regenerative potential of type I collagen membrane along with xenogenic bone graft in the treatment of periodontal intrabony defects assessed with surgical re-entry and radiographic linear and densitometric analysis.通过手术再入路以及影像学线性和密度分析评估I型胶原膜联合异种骨移植治疗牙周骨内缺损的再生潜力的临床评价。
J Indian Soc Periodontol. 2010 Jan;14(1):23-9. doi: 10.4103/0972-124X.65432.