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Association of leptin levels and relative leptin deficiency with steatotic liver disease in the general population.

作者信息

Wernly Bernhard, Beghini Marianna, Semmler Georg, Paar Vera, Lichtenauer Michael, Singhartinger Franz, Völkerer Andreas, Ausserwinkler Mathias, Flamm Maria, Aigner Elmar, Scherer Thomas, Datz Christian

机构信息

Institute of General Practice, Family Medicine and Preventive Medicine, Paracelsus Medical University of Salzburg, Salzburg, 5020, Austria.

Department of Internal Medicine 1, Paracelsus Medical University, Salzburg, Austria.

出版信息

Endocrine. 2025 Sep 16. doi: 10.1007/s12020-025-04429-y.

DOI:10.1007/s12020-025-04429-y
PMID:40956476
Abstract
摘要

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Association of leptin levels and relative leptin deficiency with steatotic liver disease in the general population.普通人群中瘦素水平及相对瘦素缺乏与脂肪性肝病的关联。
Endocrine. 2025 Sep 16. doi: 10.1007/s12020-025-04429-y.
2
Nonalcoholic Fatty Liver非酒精性脂肪肝
3
Inflammatory markers as diagnostic and precision nutrition tools for metabolic dysfunction-associated steatotic liver disease: Results from the Fatty Liver in Obesity trial.炎症标志物作为代谢功能障碍相关脂肪性肝病的诊断和精准营养工具：来自肥胖相关性脂肪肝试验的结果。
Clin Nutr. 2024 Jul;43(7):1770-1781. doi: 10.1016/j.clnu.2024.05.042. Epub 2024 May 31.
4
Steatotic Liver Disease as a Risk Enhancer in the Presence of Metabolic Syndrome.脂肪性肝病作为代谢综合征存在时的风险增强因素。
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Novel translational mouse models of metabolic dysfunction-associated steatotic liver disease comparable to human MASLD with severe obesity.与伴有严重肥胖的人类代谢功能障碍相关脂肪性肝病（MASLD）可比的新型代谢功能障碍相关脂肪性肝病的转化小鼠模型。
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World J Gastroenterol. 2025 May 28;31(20):105346. doi: 10.3748/wjg.v31.i20.105346.
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Risk of hepatic and extrahepatic outcomes associated with metabolic dysfunction-associated steatotic liver disease and metabolic dysfunction and alcohol-associated steatotic liver disease: a systematic review and meta-analysis.与代谢功能障碍相关脂肪性肝病以及代谢功能障碍和酒精相关脂肪性肝病相关的肝内和肝外结局风险：一项系统评价和荟萃分析。
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本文引用的文献

1
Liver Fibrosis Is Positively and Independently Associated with Leptin Circulating Levels in Individuals That Are Overweight and Obese: A FibroScan-Based Cross-Sectional Study.在超重和肥胖个体中，肝纤维化与循环瘦素水平呈正相关且具有独立相关性：一项基于FibroScan的横断面研究。
Nutrients. 2025 Jun 1;17(11):1908. doi: 10.3390/nu17111908.
2
The impact of leptin receptor (LepR) mutation on the development of MASLD in a murine model.瘦素受体（LepR）突变对小鼠模型中代谢相关脂肪性肝病（MASLD）发展的影响。
Gene. 2025 Aug 15;961:149550. doi: 10.1016/j.gene.2025.149550. Epub 2025 May 6.
3
Metabolic dysfunction-associated steatotic liver disease in adults.
成人代谢功能障碍相关脂肪性肝病
Nat Rev Dis Primers. 2025 Mar 6;11(1):14. doi: 10.1038/s41572-025-00599-1.
4
Evidence from clinical studies of leptin: current and future clinical applications in humans.来自瘦素临床研究的证据：瘦素在人类中的当前和未来临床应用。
Metabolism. 2024 Dec;161:156053. doi: 10.1016/j.metabol.2024.156053. Epub 2024 Oct 28.
5
Steatotic liver disease.脂肪变性肝疾病。
Lancet. 2024 Nov 2;404(10464):1761-1778. doi: 10.1016/S0140-6736(24)01811-7.
6
Evidence That Peripheral Leptin Resistance in Omental Adipose Tissue and Liver Correlates with MASLD in Humans.证据表明，人类网膜脂肪组织和肝脏的外周瘦素抵抗与 MASLD 相关。
Int J Mol Sci. 2024 Jun 11;25(12):6420. doi: 10.3390/ijms25126420.
7
Metabolic dysfunction-associated steatotic liver disease: Update and impact of new nomenclature on the American Association for the Study of Liver Diseases practice guidance on nonalcoholic fatty liver disease.代谢相关脂肪性肝病：新命名对美国肝病研究学会非酒精性脂肪性肝病实践指南的影响及更新。
Hepatology. 2024 May 1;79(5):1212-1219. doi: 10.1097/HEP.0000000000000670. Epub 2023 Nov 9.
8
Leptin increases hepatic triglyceride export via a vagal mechanism in humans.瘦素通过迷走神经机制增加人体肝脏甘油三酯的输出。
Cell Metab. 2022 Nov 1;34(11):1719-1731.e5. doi: 10.1016/j.cmet.2022.09.020. Epub 2022 Oct 10.
9
A sex-specific propensity-adjusted analysis of colonic adenoma detection rates in a screening cohort.基于性别倾向调整的筛查队列中结肠腺瘤检出率的分析。
Sci Rep. 2021 Sep 7;11(1):17785. doi: 10.1038/s41598-021-97163-0.
10
Leptin in Leanness and Obesity: JACC State-of-the-Art Review.瘦素与肥胖症和消瘦症：美国心脏病学会最新综述。
J Am Coll Cardiol. 2021 Feb 16;77(6):745-760. doi: 10.1016/j.jacc.2020.11.069.