Gu Hua, Cai Yong
Department of Neurosurgery, the First People's Hospital of Huzhou, No. 158, Guangchang Hou Road, Huzhou, 313000, Zhejiang Province, P. R. China.
Transl Stroke Res. 2025 Sep 16. doi: 10.1007/s12975-025-01383-9.
Subarachnoid hemorrhage (SAH) frequently results in early brain injury (EBI), which remains a major barrier to favorable neurological recovery. Understanding the molecular underpinnings of EBI is crucial for developing targeted therapeutics. Circular RNAs (circRNAs) have emerged as influential molecular players in various brain injury contexts. This study focuses on one such molecule, circ_0004058, examining its impact on EBI through interaction with miR-221-3p and the VE1 signaling pathway. Utilizing an established SAH rodent model, our team conducted a detailed investigation of the expression patterns and interactions involving circ_0004058. Our analyses revealed a significant post-SAH upregulation of circ_0004058, which affected miR-221-3p activity and VE1 signaling. Furthermore, functional modulation of circ_0004058 expression altered the severity of EBI, presenting evidence that it serves as a critical determinant in the injury process. The results suggest that circ_0004058 holds promise as a therapeutic target, offering new possibilities for the development of strategies to mitigate SAH-induced brain damage. Through this study, circ_0004058 is highlighted not only as a biomarker but also as a possible avenue for therapeutic modulation in SAH management.
蛛网膜下腔出血（SAH）常导致早期脑损伤（EBI），这仍然是神经功能良好恢复的主要障碍。了解EBI的分子基础对于开发靶向治疗方法至关重要。环状RNA（circRNAs）已成为各种脑损伤情况下有影响力的分子参与者。本研究聚焦于这样一种分子，即circ_0004058，通过与miR-221-3p和VE1信号通路相互作用来研究其对EBI的影响。利用已建立的SAH啮齿动物模型，我们的团队对涉及circ_0004058的表达模式和相互作用进行了详细研究。我们的分析显示，SAH后circ_0004058显著上调，这影响了miR-221-3p活性和VE1信号传导。此外，circ_0004058表达的功能调节改变了EBI的严重程度，表明它在损伤过程中起关键决定作用。结果表明，circ_0004058有望成为治疗靶点，为开发减轻SAH诱导脑损伤的策略提供了新的可能性。通过这项研究，circ_0004058不仅被视为一种生物标志物，而且是SAH管理中治疗调节的可能途径。
