Sun Yuanyang, Wang Yun, Mu Shukun, Wu Xiaofeng, Yu Suchun, Wang Zhongming
School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, China.
Department of Radiation Oncology, Shidong Hospital, Shidong Hospital Affiliated to University of Shanghai for Science and Technology, Shanghai, China.
Front Oncol. 2025 Sep 1;15:1485207. doi: 10.3389/fonc.2025.1485207. eCollection 2025.
Boron neutron capture therapy (BNCT) is a unique radiotherapy modality that targets and destroys selectively tumor cells that have absorbed boron, while leaving surrounding healthy cells unharmed. Over the course of the last nearly 40 years, several clinical studies of BNCT for melanoma have been conducted in many countries. The results of clinical studies are encouraging, suggesting that BNCT may be a potentially effective method for treating melanoma. In this work, we review the outcomes of clinical study of BNCT for melanoma. Moreover, we provide a concise overview of advancements in accelerator-based neutron source and boron delivery agent (BDA) applied to BNCT for melanoma. Finally, we discuss the areas for further research focus regarding BNCT for melanoma.
硼中子俘获疗法（BNCT）是一种独特的放射治疗方式，它能够靶向并选择性地摧毁已吸收硼的肿瘤细胞，同时使周围健康细胞不受损害。在过去近40年里，许多国家都开展了多项针对黑色素瘤的BNCT临床研究。临床研究结果令人鼓舞，表明BNCT可能是一种治疗黑色素瘤的潜在有效方法。在这项工作中，我们回顾了BNCT治疗黑色素瘤的临床研究结果。此外，我们简要概述了应用于黑色素瘤BNCT的基于加速器的中子源和硼递送剂（BDA）的进展。最后，我们讨论了黑色素瘤BNCT进一步研究的重点领域。
