Zhang Junyi, Cui Liyuan, Meng Xinhang, Luo Yujie, Ou Jingmin, Wang Songcun, Qiu Mingke
Department of Interventional Vascular Surgery, Xinhua Hospital, Shanghai JiaoTong University, School of Medicine, Shanghai, China.
Laboratory for Reproductive Immunology, Obstetrics & Gynecology Hospital of Fudan University, Shanghai, China.
Front Immunol. 2025 Sep 1;16:1665454. doi: 10.3389/fimmu.2025.1665454. eCollection 2025.
Arteriosclerosis obliterans (ASO) is a chronic vascular disease characterized by narrowing or occlusion of the vascular lumen. Its pathogenesis is complex and closely associated with lipid metabolism disorders and chronic inflammation. Although notable progress has been made in the treatment of ASO, it still remains a cause of surgical limb loss globally. In recent years, immune checkpoints have been identified as critical regulators of the immune microenvironment that play a significant role in ASO. Furthermore, immune checkpoints can affect lipid metabolism by regulating the metabolic pathways of immune cells, thereby indirectly modulating lipid metabolic processes, such as lipid absorption, transport, and degradation, which are crucial in the development and progression of atherosclerosis. Here, we summarized and discussed progress in studies related to lipid metabolism and immune checkpoints during ASO, and highlighted how immune checkpoints regulate lipid metabolism to affect ASO. Further exploration of the interactions between lipid metabolism regulators and immune checkpoints may uncover novel potential therapeutic targets for ASO management.
闭塞性动脉硬化（ASO）是一种慢性血管疾病，其特征为血管腔狭窄或闭塞。其发病机制复杂，与脂质代谢紊乱和慢性炎症密切相关。尽管在ASO的治疗方面已取得显著进展，但在全球范围内，它仍是导致肢体手术切除的一个原因。近年来，免疫检查点已被确定为免疫微环境的关键调节因子，在ASO中发挥重要作用。此外，免疫检查点可通过调节免疫细胞的代谢途径影响脂质代谢，从而间接调节脂质代谢过程，如脂质吸收、转运和降解，这些过程在动脉粥样硬化的发生和发展中至关重要。在此，我们总结并讨论了ASO期间脂质代谢与免疫检查点相关研究的进展，并强调了免疫检查点如何调节脂质代谢以影响ASO。进一步探索脂质代谢调节因子与免疫检查点之间的相互作用，可能会发现ASO治疗管理的新潜在靶点。
