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一名年轻女性原发性膀胱印戒细胞癌的罕见病例。

A Rare Case of Primary Signet Ring Cell Carcinoma of the Urinary Bladder in a Young Woman.

作者信息

Synoverskyy Pavlo, Hijazi Sameh, Krüer Thomas, Haferkamp Axel, Brandt Maximilian P

机构信息

Department for Urology, Universitätsmedizin der Johannes-Gutenberg-Universität Mainz, Mainz, Germany.

Department for Urology, Stiftung Mathias-Spital Rheine, Ibbenbüren, Germany.

出版信息

Case Rep Urol. 2025 Sep 8;2025:9204085. doi: 10.1155/criu/9204085. eCollection 2025.

Abstract

Primary signet ring cell carcinoma of the urinary bladder (PSRCCB) is an exceedingly rare subtype of urinary bladder carcinoma, comprising 0.12%-0.6% of cases, with a poor prognosis. This case report details a distinctive case of a 32-year-old woman with PSRCCB, presenting without typical risk factors and posing diagnostic and therapeutic challenges. Initial symptoms included urinary tract infection and lower abdominal pain. Imaging and histological assessments identified a mucinous adenocarcinoma with signet ring cell components. The patient underwent curative open partial cystectomy, given her young age and localized tumor, avoiding lymphadenectomy and adjuvant chemotherapy due to complete tumor resection and absence of metastases. Postoperative follow-up showed no pathological findings, underscoring the importance of individualized treatment strategies in rare cancer cases. This case contributes to the limited data on PSRCCB and its management.

摘要

膀胱原发性印戒细胞癌(PSRCCB)是膀胱癌中一种极其罕见的亚型,占病例的0.12%-0.6%,预后较差。本病例报告详细介绍了一名32岁患有PSRCCB的独特女性病例,该患者没有典型的危险因素,给诊断和治疗带来了挑战。初始症状包括尿路感染和下腹部疼痛。影像学和组织学评估确定为伴有印戒细胞成分的黏液腺癌。鉴于患者年轻且肿瘤局限,患者接受了根治性开放性部分膀胱切除术,由于肿瘤完全切除且无转移,避免了淋巴结清扫和辅助化疗。术后随访未发现病理结果,强调了罕见癌症病例个体化治疗策略的重要性。本病例为PSRCCB及其治疗的有限数据增添了内容。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bcc/12436014/d49255329bdc/CRIU2025-9204085.001.jpg

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