慢性阻塞性肺疾病女性患者中的嗜酸性粒细胞性细胞因子与小气道功能障碍：与接触生物质烟雾和吸烟的相关性
Eosinophilic cytokines and small airway dysfunction in women with COPD: correlation with exposure to biomass smoke versus tobacco smoking.
作者信息
Robles-Hernández R, Pérez-Padilla R, Ramírez-Venegas A, Velasco-Torres Y, Montaño M, Ramos C, Ramírez-GarciaLuna A S, Pérez-Bautista O
机构信息
Departmento de Investigación en Tabaquismo y EPOC, Instituto Nacional de Enfermedades respiratorias 'Ismael Cosío Villegas,' Tlalpan Mexico City, Mexico.
Laboratorio de Biología Celular, Departamento de Investigación en Fibrosis Pulmonar, Instituto Nacional de Enfermedades respiratorias 'Ismael Cosío Villegas,' Tlalpan Mexico City, Mexico.
出版信息
IJTLD Open. 2025 Sep 10;2(9):527-534. doi: 10.5588/ijtldopen.24.0666. eCollection 2025 Sep.
BACKGROUND
Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease characterised by progressive airflow obstruction. Tobacco smoking is the leading cause of COPD (COPD-TS); however, chronic exposure to biomass smoke (COPD-BS) is the second risk factor. COPD-TS and COPD-BS are now considered different phenotypes, with COPD-BS having small airway dysfunction (SAD).
OBJECTIVES
Our primary aim was to investigate the correlation between SAD and the serum levels of interleukins implicated in the maturation and recruitment of eosinophils in women with COPD-BS and COPD-TS.
METHODS
This cross-sectional study included 25 women with COPD-BS and 25 women with COPD-TS, and the relationship with SAD was assessed by impulse oscillometry (IOS), alongside measurements of interleukins (IL-1ra, IL-2, IL-4, IL-8, IL-9, IL-13, and IL-17) and eotaxin using the multiplex test (Bio-Plex), in addition to eosinophils total blood.
RESULTS
Blood eosinophil count, cytokines, and eotaxin were higher in COPD-BS relative to COPD-TS. IOS measurements were higher in COPD-BS than in COPD-TS. R5-R20 positively correlated with the concentrations of all measured cytokines noted if COPD groups were analysed separately ( < 0.01).
CONCLUSION
Eosinophil counts and cytokines in COPD-BS positively correlate with small airway resistance as measured by IOS in R5-R20.
背景
慢性阻塞性肺疾病（COPD）是一种以进行性气流受限为特征的慢性炎症性疾病。吸烟是COPD（COPD-TS）的主要病因；然而，长期暴露于生物质烟雾（COPD-BS）是第二个危险因素。COPD-TS和COPD-BS现在被认为是不同的表型，COPD-BS存在小气道功能障碍（SAD）。
目的
我们的主要目的是研究COPD-BS和COPD-TS女性患者中SAD与参与嗜酸性粒细胞成熟和募集的白细胞介素血清水平之间的相关性。
方法
这项横断面研究纳入了25例COPD-BS女性患者和25例COPD-TS女性患者，通过脉冲振荡法（IOS）评估与SAD的关系，同时使用多重检测法（Bio-Plex）测量白细胞介素（IL-1ra、IL-2、IL-4、IL-8、IL-9、IL-13和IL-17）和嗜酸性粒细胞趋化因子，此外还检测全血嗜酸性粒细胞。
结果
与COPD-TS相比，COPD-BS患者的血嗜酸性粒细胞计数、细胞因子和嗜酸性粒细胞趋化因子更高。COPD-BS患者的IOS测量值高于COPD-TS患者。如果分别分析COPD组，R5-R20与所有测量细胞因子的浓度呈正相关（<0.01）。
结论
COPD-BS患者的嗜酸性粒细胞计数和细胞因子与IOS测量的R5-R20小气道阻力呈正相关。
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