Tsanev A, Zlateva S, Khristov V, Petkova M
Vutr Boles. 1985;24(6):107-11.
Via the artificial endocrine pancreas--apparatus "BIOSTATOR" 100 patients were studied and treated, namely: 90 with diabetes mellitus, 7 with hyperinsulinism and 3 with obesity. The 24-h insulin needs of the diabetics with insulin-dependent and non-insulin dependent with secondary exhaustion type of diabetes, were determined. The following subcutaneous insulin dosage was determined, depending on the insulin amount spent during the 24-h biostator control. It was established that the necessary reduction of the intravenously administered insulin is 30% on the average with the passing over to subcutaneous regime. The indices of lipid metabolism were also studied as well as numerous hormones with which the carbohydrate compensation leads to a change. The problem of the "morning" phenomenon is discussed.
通过人工内分泌胰腺——“生物调节器”设备对100名患者进行了研究和治疗，具体如下：90例糖尿病患者、7例高胰岛素血症患者和3例肥胖患者。测定了胰岛素依赖型和非胰岛素依赖型继发性衰竭型糖尿病患者24小时的胰岛素需求量。根据24小时生物调节器控制期间消耗的胰岛素量确定了以下皮下胰岛素剂量。结果表明，平均而言，过渡到皮下给药方案后，静脉注射胰岛素的必要减少量为30%。还研究了脂质代谢指标以及碳水化合物补偿导致变化的多种激素。讨论了“黎明”现象的问题。
