Rydberg Mattias, Dahlin Lars B, Nilsson Peter M, Zimmerman Malin
Department of Hand Surgery, Lund University, Skåne University Hospital, Malmö, Sweden.
Department of Translational Medicine-Hand Surgery, Lund University, Lund, Sweden.
Int J Obes (Lond). 2025 Sep 17. doi: 10.1038/s41366-025-01899-y.
Ulnar nerve entrapment (UNE) is a common disorder with many associated risk factors. Diabetes mellitus (DM) is an established risk factor, but less is known about metabolic risk factors in individuals without diabetes. Our study aimed to explore the association of body mass index (BMI) with UNE during long-term follow-up.
The population-based cohort study Malmö Diet and Cancer Study (MDCS) and the Swedish Patient Register (NPR) were cross-linked. Between 1991 and 1996, 30,446 subjects were recruited to MDCS and were followed to a diagnosis of UNE, emigration, death, or end of study on December 31, 2020. BMI at study entry was stratified into normal weight (<25), overweight (25-30) and obesity (>30). To omit the effect of DM, individuals with prevalent or incident DM were excluded. To calculate the association between BMI and incident UNE, Cox proportional hazard models adjusted for age, sex, hypertension, smoking, manual work, and alcohol consumption were used.
A total of 23,254 individuals were followed for over 25 years, whereof 192 (0.8%) developed UNE. In the multivariable Cox regression models, BMI was independently associated with UNE (HR 1.07; 95% CI 1.03-1.11, p < 0.001). Both overweight (HR 1.55; 95% CI 1.12-2.15, p < 0.01) and obesity (HR 2.23; 95% CI 1.40-3.57, p = 0.001) were associated with an increased risk compared to individuals with normal weight.
High BMI is associated with the development of UNE in individuals without diabetes, indicating that high BMI is an independent risk factor for the development of nerve entrapment disorders irrespective of hyperglycaemia.
尺神经卡压（UNE）是一种常见疾病，有许多相关风险因素。糖尿病（DM）是已确定的风险因素，但对于无糖尿病个体的代谢风险因素了解较少。我们的研究旨在探讨长期随访期间体重指数（BMI）与UNE之间的关联。
基于人群的队列研究马尔默饮食与癌症研究（MDCS）与瑞典患者登记册（NPR）进行了交叉链接。1991年至1996年期间，30446名受试者被纳入MDCS，并随访至UNE诊断、移民、死亡或2020年12月31日研究结束。研究开始时的BMI被分层为正常体重（<25）、超重（25-30）和肥胖（>30）。为排除DM的影响，患有现患或新发DM的个体被排除。为计算BMI与新发UNE之间的关联，使用了调整年龄、性别、高血压、吸烟、体力劳动和饮酒情况的Cox比例风险模型。
共有23254名个体被随访超过25年，其中192人（0.8%）发生了UNE。在多变量Cox回归模型中，BMI与UNE独立相关（风险比1.07；95%置信区间1.03-1.11，p<0.001）。与正常体重个体相比，超重（风险比1.55；95%置信区间1.12-2.15，p<0.01）和肥胖（风险比2.23；95%置信区间1.40-3.57，p=0.001）均与风险增加相关。
高BMI与无糖尿病个体发生UNE相关，表明高BMI是神经卡压性疾病发生的独立风险因素，与高血糖无关。
