Dai Mengjun, She Yuhang, Wang Hao
1 Department of Anesthesia Operating Room, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing City, Jiangsu, China.
Department of Urology, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing City, Jiangsu, China.
Front Pharmacol. 2025 Sep 2;16:1639032. doi: 10.3389/fphar.2025.1639032. eCollection 2025.
To assess the efficacy of mirabegron in patients with intramural ureteral stones (6-10 mm).
We prospectively randomized 92 patients with intramural ureteral stones into two groups. Patients in the mirabegron group received 50 mg of mirabegron daily, while those in the tamsulosin group received 0.4 mg tamsulosin daily. All patients were required to use the Urinary Sensation Scale (USS) to assess the urinary urgency and the Visual Analog Scale (VAS) to assess pain. Patients were followed until stone expulsion or for up to 4 weeks.
All of 80 patients were included in this study. 41 patients in mirabegron group and 39 patients in tamsulosin group as control. The average expulsion time was shorter in mirabegron group than in tamsulosin group (8.4 ± 2.9 vs. 11.2 ± 3.1 days, < 0.0001). The stone expulsion rate (SER) was higher in mirabegron group than in tamsulosin group on 1 and 2 weeks (36.6% vs. 15.4%, = 0.031 and 75.6% vs. 43.6%, = 0.004). However, the SER on 4 weeks had no statistical difference between two groups ( > 0.05). Post-treatment VAS and USS scores were lower in mirabegron group than tamsulosin group ( < 0.05).
Mirabegron not only accelerates the expulsion of intramural ureteral stones but also relieves renal colic and vesical irritability.
评估米拉贝隆对壁内输尿管结石（6 - 10毫米）患者的疗效。
我们将92例壁内输尿管结石患者前瞻性随机分为两组。米拉贝隆组患者每日服用50毫克米拉贝隆，坦索罗辛组患者每日服用0.4毫克坦索罗辛。所有患者均需使用尿意量表（USS）评估尿急情况，并使用视觉模拟量表（VAS）评估疼痛情况。对患者进行随访直至结石排出或长达4周。
本研究共纳入80例患者。米拉贝隆组41例患者，坦索罗辛组39例患者作为对照。米拉贝隆组的平均排石时间短于坦索罗辛组（8.4 ± 2.9天对11.2 ± 3.1天，< 0.0001）。在第1周和第2周，米拉贝隆组的结石排出率（SER）高于坦索罗辛组（36.6%对15.4%，P = 0.031；75.6%对43.6%，P = 0.004）。然而，两组在第4周的SER无统计学差异（P > 0.05）。米拉贝隆组治疗后的VAS和USS评分低于坦索罗辛组（P < 0.05）。
米拉贝隆不仅能加速壁内输尿管结石的排出，还能缓解肾绞痛和膀胱刺激症状。
