Yang Yan, Li Li, Yang Mi
The Fourth People's Hospital of Chengdu, Chengdu, Sichuan, China.
The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Front Psychiatry. 2025 Sep 2;16:1658334. doi: 10.3389/fpsyt.2025.1658334. eCollection 2025.
To investigate the severity and influencing factors of hyperprolactinemia (HPRL) in hospitalized schizophrenia patients.
This retrospective study enrolled schizophrenia inpatients from a tertiary psychiatric hospital (2022-2023) with monitored prolactin (PRL) levels. Participants were categorized into normal PRL, mild HPRL, moderate HPRL, and severe HPRL groups. Laboratory indices and medication information were collected, and an ordered logistic regression modeling was conducted to analyze the influence of HPRL severity.
Among 3,641 hospitalized schizophrenia patients, 2,519 (69.18%) underwent PRL monitoring during hospitalization. A total of 1,425 patients were included for HPRL severity analysis, with 903 (63.40%) exhibiting HPRL (mild: 52.05%, moderate: 30.01%, severe: 17.94%). The mean PRL level was 983.66 ± 1001.98 mIU/L, with severe HPRL reaching 3233.66 ± 1001.98 mIU/L. The ordered multivariate logistic regression model showed that HPRL severity was negatively correlated with aripiprazole use, male sex, fasting glucose, aspartate aminotransferase (AST), and follicle-stimulating hormone (FSH), but positively correlated with the use of sulpiride, paliperidone, amisulpride, risperidone, blonanserin, trihexyphenidyl, and anxiolytics.
HPRL is highly prevalent in schizophrenia patients, with distinct clinical profiles across severity levels. HPRL severity is associated with specific antipsychotics, anxiolytics, trihexyphenidyl, and metabolic indicators, underscoring the need for risk stratification and individualized management.
探讨住院精神分裂症患者高催乳素血症（HPRL）的严重程度及其影响因素。
本回顾性研究纳入了一家三级精神病医院（2022 - 2023年）中催乳素（PRL）水平受到监测的精神分裂症住院患者。参与者被分为PRL正常组、轻度HPRL组、中度HPRL组和重度HPRL组。收集实验室指标和用药信息，并进行有序逻辑回归建模以分析HPRL严重程度的影响因素。
在3641例住院精神分裂症患者中，2519例（69.18%）在住院期间接受了PRL监测。共1425例患者纳入HPRL严重程度分析，其中903例（63.40%）存在HPRL（轻度：52.05%，中度：30.01%，重度：17.94%）。PRL平均水平为983.66±1001.98 mIU/L，重度HPRL达到3233.66±1001.98 mIU/L。有序多变量逻辑回归模型显示，HPRL严重程度与阿立哌唑使用、男性、空腹血糖、天门冬氨酸氨基转移酶（AST）和促卵泡生成素（FSH）呈负相关，但与舒必利、帕利哌酮、氨磺必利、利培酮、布南色林、苯海索和抗焦虑药的使用呈正相关。
HPRL在精神分裂症患者中高度流行，不同严重程度水平具有不同的临床特征。HPRL严重程度与特定抗精神病药物、抗焦虑药、苯海索和代谢指标相关，强调了风险分层和个体化管理的必要性。
