Mao XiuLei, Yang Sha
Department of Physical Education and Health, Lyuliang University, Lvliang, Shanxi, China.
Front Nutr. 2025 Sep 2;12:1624047. doi: 10.3389/fnut.2025.1624047. eCollection 2025.
Emerging evidence highlights the synergistic potential of polyphenols and exercise in modulating molecular pathways critical for brain function, tumor suppression, and healthy aging. Both interventions independently influence oxidative stress, inflammation, apoptosis, autophagy, metabolic regulation, and neuroplasticity-key processes implicated in head and neck cancers (HNCs) development, neurodegeneration, and lifespan determination. Recent studies reveal that polyphenols, through their antioxidant and epigenetic-modifying properties, enhance neuronal resilience, suppress tumorigenesis, and improve metabolic homeostasis. Simultaneously, exercise activates signaling cascades, promoting neurogenesis, immune modulation, and anti-cancer effects. The molecular crosstalk between polyphenol intake and physical activity appears to amplify protective mechanisms, offering novel therapeutic strategies for brain health preservation, HNCs management, and metabolic optimization. This review critically examines the interconnected pathways influenced by polyphenols and exercise, their combined impact on brain function and tumor suppression, and discusses the translational potential for extending healthy lifespan through integrated lifestyle interventions.
新出现的证据凸显了多酚类物质与运动在调节对脑功能、肿瘤抑制和健康衰老至关重要的分子途径方面的协同潜力。这两种干预措施各自独立影响氧化应激、炎症、细胞凋亡、自噬、代谢调节以及神经可塑性，而这些关键过程与头颈癌（HNCs）的发展、神经退行性变和寿命决定有关。最近的研究表明，多酚类物质通过其抗氧化和表观遗传修饰特性，增强神经元弹性、抑制肿瘤发生并改善代谢稳态。同时，运动激活信号级联反应，促进神经发生、免疫调节和抗癌作用。多酚类物质摄入与体育活动之间的分子相互作用似乎会放大保护机制，为脑健康保护、HNCs管理和代谢优化提供新的治疗策略。本综述批判性地审视了受多酚类物质和运动影响的相互关联途径、它们对脑功能和肿瘤抑制的综合影响，并讨论了通过综合生活方式干预延长健康寿命的转化潜力。
