抑郁症患者下丘脑-垂体-甲状腺轴的功能
Function of hypothalamo-pituitary thyroid axis in depressed patients.
作者信息
Yamaguchi T, Hatotani N, Nomura J, Ushijima Y
出版信息
Folia Psychiatr Neurol Jpn. 1977;31(2):173-81. doi: 10.1111/j.1440-1819.1977.tb02718.x.
Abstract
Nineteen out of 51 depressed patients showed abnormal TSH response to TRH in terms of exaggerated, diminished and delayed responses. The basal value of T3 and its response to TRH were significantly lower in patients with delayed or diminished response than in the normal subjects. These results indicate that the dysfunction of the hypothalamo-pituitary thyroid axis plays an important role in the pathogenesis of depression.
摘要
51名抑郁症患者中有19名患者的促甲状腺激素（TSH）对促甲状腺激素释放激素（TRH）的反应异常，表现为反应过度、减弱和延迟。反应延迟或减弱的患者的T3基础值及其对TRH的反应明显低于正常受试者。这些结果表明，下丘脑-垂体-甲状腺轴功能障碍在抑郁症的发病机制中起重要作用。
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