[嗜酸性粒细胞性肉芽肿性多血管炎中嗜酸性粒细胞在胃肠道的分布]
[Distribution of eosinophilic granulocytes in the gastrointestinal tract in EGPA].
作者信息
Rogalski Svenja, Schumacher Udo, Hellmich Bernhard, Ebsen Michael, Bremer Jan Phillip, Ullrich Sebastian
机构信息
Lungenzentrum Stade, Harsefelder Str. 6, 21680, Stade, Deutschland.
Institut für Anatomie und Experimentelle Morphologie, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Deutschland.
出版信息
Z Rheumatol. 2025 Sep 18. doi: 10.1007/s00393-025-01723-y.
BACKGROUND
Gastrointestinal involvement is common in eosinophilic granulomatosis with polyangiitis (EGPA) and has a poor prognosis.
OBJECTIVES
The aim of our study was to determine the density of eosinophils in the gastrointestinal tract that should be considered pathological in patients with EGPA, and how clinically and prognostically relevant intramucosal eosinophil accumulation is in patients with EGPA.
METHODS
Forty-nine subjects were included in the study: 18 with EGPA (9 women) and as a control group 31 with other rheumatological inflammatory diseases. Two hundred and forty-four biopsies from the gastrointestinal tract of the study participants were analyzed.
RESULTS
Histologically, there was no significant difference in eosinophil counts between patients with EGPA and the control group; however, there was an increased density when macroscopic gastrointestinal inflammation was already present.
CONCLUSIONS
Biopsies from macroscopically unremarkable mucosa appear to have limited diagnostic utility.
背景
胃肠道受累在嗜酸性肉芽肿性多血管炎（EGPA）中很常见，且预后较差。
目的
我们研究的目的是确定EGPA患者胃肠道中应被视为病理性的嗜酸性粒细胞密度，以及EGPA患者黏膜内嗜酸性粒细胞积聚在临床和预后方面的相关性。
方法
49名受试者纳入研究：18名EGPA患者（9名女性），以及作为对照组的31名患有其他风湿性炎症性疾病的患者。对研究参与者胃肠道的244份活检样本进行了分析。
结果
组织学上，EGPA患者与对照组的嗜酸性粒细胞计数无显著差异；然而，当出现宏观胃肠道炎症时，密度会增加。
结论
来自宏观上无明显异常黏膜的活检样本似乎诊断效用有限。
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