Berchenko G N, Shekhter A B, Nikolaev A V, Kharitonov Iu K, Berchenko V V
Arkh Patol. 1985;47(12):37-44.
The dynamics of purulent wound healing developing in patients surgically treated for phlegmons or abscesses was studied histochemically and electron microscopically on the material of successive biopsies. It was shown that purulent wound healing is characterized by the desynchronization of inflammation and regeneration associated with the reduced macrophagal response and disturbances of the microcirculation system. Collagen sponge reduces inflammatory changes, activates the macrophage reaction, restores intercellular interactions, normalizes the microcirculation system, enhances proliferation and differentiation of fibroblasts, collagen synthesis and secretion, processes of fibrillogenesis, maturation of granulation tissue, epithelialization.
对因蜂窝织炎或脓肿接受手术治疗患者的化脓性伤口愈合动态进行了组织化学和电子显微镜研究，取材于连续活检标本。结果表明，化脓性伤口愈合的特征是炎症与再生不同步，这与巨噬细胞反应减弱和微循环系统紊乱有关。胶原海绵可减轻炎症变化，激活巨噬细胞反应，恢复细胞间相互作用，使微循环系统正常化，增强成纤维细胞的增殖与分化、胶原合成与分泌、原纤维形成过程、肉芽组织成熟及上皮形成。
