Porter F L, Marshall R E, Moore J A, Miller R H
Am J Perinatol. 1985 Apr;2(2):63-6. doi: 10.1055/s-2007-999915.
The use of prophylactic phenobarbital to reduce motor activity and intraventricular hemorrhage was investigated in a controlled exploratory trial with 19 low birthweight premature infants with respiratory disease. Although phenobarbital significantly suppressed movement, it was associated with an increased incidence of intraventricular hemorrhage (IVH). Phenobarbital-treated infants were over eight times more likely to experience IVH than were untreated infants. These data indicate that inhibition of motor activity by phenobarbital may not alleviate the key pathogenetic factors in IVH.
在一项针对19名患有呼吸系统疾病的低出生体重早产儿的对照探索性试验中，研究了使用预防性苯巴比妥来减少运动活动和脑室内出血的情况。尽管苯巴比妥显著抑制了运动，但它与脑室内出血（IVH）发生率的增加有关。接受苯巴比妥治疗的婴儿发生IVH的可能性是未治疗婴儿的八倍多。这些数据表明，苯巴比妥对运动活动的抑制可能无法减轻IVH的关键致病因素。
