在护士健康研究II中，良性乳腺活检女性的出生体重、身高和体重指数与干细胞标志物表达的关系。
Birthweight, height, and body mass index in relation to the expression of stem cell markers among women with benign breast biopsies in the Nurses' Health Study II.
作者信息
Oh Hannah, Yaghjyan Lusine, Heng Yujing J, Baker Gabrielle M, Sardella Brian R, Mahoney Matt B, Murthy Divya, Rosner Bernard, Tamimi Rulla M
机构信息
Department of Health Policy and Management, Korea University, Seoul, South Korea.
Interdisciplinary Program in Precision Public Health, Department of Public Health Sciences, Korea University, Seoul, South Korea.
出版信息
Br J Cancer. 2025 Sep 18. doi: 10.1038/s41416-025-03194-z.
BACKGROUND
The amount and activity of breast stem cell population may play an important role in breast carcinogenesis. However, little is known about whether early-life and adult anthropometric measures, including body mass index (BMI), birthweight, and height, are associated with stem cell marker expressions in non-cancerous breast tissue.
METHODS
Among 730 women with biopsy-confirmed benign breast disease (BBD) in the Nurses' Health Study II, we quantified immunohistochemical staining of stem cell markers (CD44, CD24, ALDH1A1) in histopathologically normal epithelial and stromal breast tissue. Linear regression was conducted to estimate the associations of anthropometric measures with stem cell marker expression, adjusting for potential confounders.
RESULTS
BMI at age 18 (≥23.0 vs. <19.0 kg/m), BMI at benign breast biopsy (≥30.0 vs. <21.0 kg/m), and change in BMI since age 18 (>7.0 vs. ≤0 kg/m) were inversely associated with CD44 expression levels in epithelium and stroma combined (β [95% CI]= -0.30 [-0.55, -0.04]; -0.34 [-0.59, -0.08]; -0.38 [-0.65, -0.10]; respectively). Change in BMI since age 18 (>7.0 vs. ≤0 kg/m) was also inversely associated with ALDH1A1 expression in epithelium (-0.31 [-0.62, -0.001]) and stroma (-0.63 [-1.18, -0.08]). Birthweight and height were not associated.
CONCLUSION
Adiposity measures may be associated with stem cell marker expression among cancer-free women.
背景
乳腺干细胞群体的数量和活性可能在乳腺癌发生过程中起重要作用。然而，关于包括体重指数（BMI）、出生体重和身高在内的早年及成年人体测量指标是否与非癌性乳腺组织中的干细胞标志物表达相关，目前知之甚少。
方法
在护士健康研究II中730例经活检确诊为良性乳腺疾病（BBD）的女性中，我们对组织病理学正常的乳腺上皮和间质组织中的干细胞标志物（CD44、CD24、ALDH1A1）进行免疫组化染色定量。进行线性回归以估计人体测量指标与干细胞标志物表达之间的关联，并对潜在混杂因素进行校正。
结果
18岁时的BMI（≥23.0 vs. <19.0kg/m²）、良性乳腺活检时的BMI（≥30.0 vs. <21.0kg/m²）以及自18岁以来BMI的变化（>7.0 vs. ≤0kg/m²）与上皮和间质中CD44表达水平呈负相关（β[95%CI]分别为-0.30[-0.55, -0.04]；-0.34[-0.59, -0.08]；-0.38[-0.65, -0.10]）。自18岁以来BMI的变化（>7.0 vs. ≤0kg/m²）也与上皮中ALDH1A1表达（-0.31[-0.62, -0.001]）和间质中ALDH1A1表达（-0.63[-1.18, -0.08]）呈负相关。出生体重和身高与之无关。
结论
肥胖指标可能与无癌女性的干细胞标志物表达相关。
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