Erdem Duygu, Eliçora Sultan Şevik, Güven Berrak, Baklaci Deniz
Department of Otorhinolaryngology, Faculty of Medicine, Zonguldak Bülent Ecevit University, Zonguldak, Türkiye.
Department of Otorhinolaryngology, Kocaeli City Hospital, Kocaeli, Türkiye.
Front Neurol. 2025 Sep 3;16:1660767. doi: 10.3389/fneur.2025.1660767. eCollection 2025.
Although otosclerosis is a common disease, its etiology has not yet been clearly elucidated. One of the factors recently implicated in its pathogenesis is chronic inflammation. Blood count parameters are known as classical inflammatory markers in several diseases. Raftlin is also a novel biomarker of inflammation. The present study aimed to investigate Raftlin levels and blood count parameters in otosclerosis.
The study included 50 otosclerosis patients and 50 healthy volunteers. Serum Raftlin levels and white blood cell, neutrophil, lymphocyte and platelet counts, neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and mean platelet volume (MPV) were measured in otosclerosis patients and compared with the controls.
White blood cell and neutrophil counts and NLR were statistically higher in otosclerosis patients than in the control group ( < 0.001). There was no statistically significant difference between the control and patient groups in lymphocyte and platelet counts, and MPV and PLR values. The Raftlin level was also statistically significantly higher in otosclerosis patients than in the control group ( = 0.001).
The Raftlin level and NLR value were significantly higher in otosclerotic patients than in healthy controls, supporting the presence of an inflammatory etiology for otosclerosis. Our study is the first in the literature to investigate the relationship between otosclerosis and Raftlin with known inflammatory markers.
尽管耳硬化症是一种常见疾病，但其病因尚未完全阐明。最近涉及其发病机制的因素之一是慢性炎症。血细胞计数参数在多种疾病中被视为经典的炎症标志物。Raftlin也是一种新型的炎症生物标志物。本研究旨在调查耳硬化症患者的Raftlin水平和血细胞计数参数。
该研究纳入了50例耳硬化症患者和50名健康志愿者。测量耳硬化症患者的血清Raftlin水平、白细胞、中性粒细胞、淋巴细胞和血小板计数、中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）以及平均血小板体积（MPV），并与对照组进行比较。
耳硬化症患者的白细胞、中性粒细胞计数和NLR在统计学上高于对照组（<0.001）。淋巴细胞和血小板计数、MPV和PLR值在对照组和患者组之间无统计学显著差异。耳硬化症患者的Raftlin水平在统计学上也显著高于对照组（=0.001）。
耳硬化症患者的Raftlin水平和NLR值显著高于健康对照组，支持耳硬化症存在炎症病因。我们的研究是文献中首次调查耳硬化症与Raftlin以及已知炎症标志物之间关系的研究。
