Barrientos-Villegas Stefany, García-Álvarez María Isabel, Vidal Juana L, Gómez-Osorio Luis M, López-Osorio Sara, Chaparro-Gutiérrez Jenny J
CIVAB Research Group, Faculty of Agricultural Sciences, University of Antioquia (UdeA), Medellín, Colombia.
Front Vet Sci. 2025 Sep 3;12:1614486. doi: 10.3389/fvets.2025.1614486. eCollection 2025.
To determine the frequency of phenotypic and genotypic resistance to quinolones and fluoroquinolones in spp. isolated from production animals (pigs, poultry, cattle) and rodents in South America between 2020 and 2024, with the goal of providing key information on resistance in these countries for public health and food safety.
A systematic review was conducted following the PRISMA guidelines, using databases such as Scopus, PubMed, SciELO, and Latindex. Studies on spp. resistant to quinolones and fluoroquinolones in production animals, meat products, and rodents in South America during 2020-2024 were included.
Of the 83 initial results, 27 studies were selected. 70.4% of the studies were conducted in Brazil. 88% of the studies ( = 24/27) used phenotypic methods, with the disk diffusion technique being the most common. Ciprofloxacin was the most studied antibiotic, with an overall resistance of 32.5%, followed by nalidixic acid (60.6%) and enrofloxacin (23.7%). The average multidrug resistance (MDR) was 62%. 44% of the studies ( = 12/27) employed genotypic methods, with whole genome sequencing (WGS) being the most notable technique. Mutations were reported in (58%), (50%), (8%), and the presence of genes (75%) and (8%). No studies on rodents were found.
Resistance to quinolones and fluoroquinolones in spp. in South America endangers public health and food safety. To address antimicrobial resistance, monitoring and control measures must be implemented, regional research should be promoted, and stronger restrictions should be enforced.
确定2020年至2024年期间从南美洲生产动物（猪、家禽、牛）和啮齿动物中分离出的 菌对喹诺酮类和氟喹诺酮类药物的表型和基因型耐药频率，旨在为这些国家的公共卫生和食品安全提供有关耐药性的关键信息。
按照PRISMA指南进行系统评价，使用Scopus、PubMed、SciELO和Latindex等数据库。纳入2020 - 2024年期间南美洲生产动物、肉类产品和啮齿动物中对喹诺酮类和氟喹诺酮类耐药的 菌的研究。
在83个初始结果中，选择了27项研究。70.4%的研究在巴西进行。88%的研究（n = 24/27）采用表型方法，其中纸片扩散法最为常见。环丙沙星是研究最多的抗生素，总体耐药率为32.5%，其次是萘啶酸（60.6%）和恩诺沙星（23.7%）。平均多重耐药（MDR）率为62%。44%的研究（n = 12/27）采用基因型方法，全基因组测序（WGS）是最显著的技术。报告了 （58%）、 （50%）、 （8%）中的突变，以及 基因（75%）和 （8%）的存在。未发现关于啮齿动物的研究。
南美洲 菌对喹诺酮类和氟喹诺酮类的耐药性危及公共卫生和食品安全。为应对抗菌药物耐药性，必须实施监测和控制措施，促进区域研究，并加强限制措施。
