Baxla Vineeta, Sharma Ashok Kumar, Seema Kumari, Kumar Abhay, Boipai Manju, Bhattacharya Pradip Kumar, Kumar Manoj
Department of Microbiology, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India.
Department of Critical Care Medicine, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India.
J West Afr Coll Surg. 2025 Oct-Dec;15(4):457-462. doi: 10.4103/jwas.jwas_132_24. Epub 2025 Feb 4.
Sepsis is undeniably a serious worldwide health threat, causing millions of deaths each year and a real diagnostic challenge to the clinicians. The conventional standard culture methods are often negative and time-consuming; therefore, alternatively specific and easily measurable biomarkers could help in predicting the diagnosis and prognosis of sepsis, as well as monitor the response to the treatments. This study will compare the role of the three markers procalcitonin (PCT), C-reactive protein (CRP), and presepsin in the diagnosis of sepsis in suspected patients admitted to a tertiary care hospital in eastern India.
A hospital-based cross-sectional study was conducted from April 2021 to March 2022. Blood samples were collected from the patients admitted in various intensive care units with evidence of sepsis and the biomarkers were estimated.
Presepsin was found to be the best among the three biomarkers with sensitivity 89.1% and specificity 88.9%, followed by PCT with sensitivity 82.7% and specificity 80%, and then CRP with sensitivity 74.5% and specificity 75.6%. The diagnostic accuracy of presepsin was also found to be maximum as its area under the receiver-operating characteristic (ROC) curve was highest (0.858) followed by PCT whose area under the ROC curve was 0.793, and then CRP with area under the ROC curve 0.741.
Based on the result of the present study, biomarkers were found to be quick, easy and effective test for diagnosing sepsis, and presepsin proved to be the most promising marker for diagnosis of sepsis as compared to PCT or CRP.
脓毒症无疑是全球范围内严重的健康威胁，每年导致数百万人死亡，对临床医生来说是一项真正的诊断挑战。传统的标准培养方法往往呈阴性且耗时；因此，特异性强且易于测量的生物标志物有助于预测脓毒症的诊断和预后，以及监测治疗反应。本研究将比较降钙素原（PCT）、C反应蛋白（CRP）和可溶性髓系细胞触发受体-1（presepsin）这三种标志物在印度东部一家三级医院收治的疑似脓毒症患者诊断中的作用。
于2021年4月至2022年3月进行了一项基于医院的横断面研究。从入住各个重症监护病房且有脓毒症证据的患者中采集血样，并对生物标志物进行评估。
在这三种生物标志物中，可溶性髓系细胞触发受体-1表现最佳，敏感性为89.1%，特异性为88.9%，其次是降钙素原，敏感性为82.7%，特异性为80%，然后是C反应蛋白，敏感性为74.5%，特异性为75.6%。可溶性髓系细胞触发受体-1的诊断准确性也最高，其受试者工作特征（ROC）曲线下面积最大（0.858），其次是降钙素原，ROC曲线下面积为0.793，然后是C反应蛋白，ROC曲线下面积为0.741。
基于本研究结果，生物标志物被发现是诊断脓毒症的快速、简便且有效的检测方法，与降钙素原或C反应蛋白相比，可溶性髓系细胞触发受体-1被证明是诊断脓毒症最有前景的标志物。
