Ping Xinglin, Zhou Haibin, Zhang Yumeng, Liu Xiaoliang, Tao Tao, Liu Qun, Feng Shangzhi, Lou Kecheng
Department of Urology, Jiujiang City Key Laboratory of Cell Therapy, JiuJiang No.1 People's Hospital, Jiujiang, Jiangxi, People's Republic of China.
Department of Urology, Jiujiang University Clinic College/Hospital, Jiujiang, Jiangxi, People's Republic of China.
Int J Nanomedicine. 2025 Sep 13;20:11249-11266. doi: 10.2147/IJN.S547834. eCollection 2025.
Erectile dysfunction refers to the inability of men to achieve or maintain sufficient erection during sexual activity, which significantly impacts their quality of life and mental health. The causes of erectile dysfunction are complex, involving multiple systems such as vascular, neural, endocrine, and psychological factors. Current treatment methods for erectile dysfunction have significant limitations in addressing organic lesions, particularly penile fibrosis and hypoxic microenvironments. However, the latest stem cell-derived nanovesicle technology has been found to significantly reverse cellular fibrosis and alter the cellular microenvironment, potentially offering a new therapeutic approach for erectile dysfunction. Additionally, extracellular vesicles derived from stem cells can exert stem cell-like regenerative effects while overcoming challenges associated with cell therapy, making them excellent tools for regenerative repair. Therefore, this paper summarizes the potential of extracellular vesicles from different stem cell sources in the treatment of erectile dysfunction and analyzes their engineered preclinical studies to facilitate their translation from the laboratory to clinical applications.
勃起功能障碍是指男性在性活动期间无法达到或维持足够的勃起，这对他们的生活质量和心理健康有重大影响。勃起功能障碍的病因复杂，涉及血管、神经、内分泌和心理因素等多个系统。目前治疗勃起功能障碍的方法在解决器质性病变方面存在重大局限性，尤其是阴茎纤维化和缺氧微环境。然而，最新的干细胞衍生纳米囊泡技术已被发现能显著逆转细胞纤维化并改变细胞微环境，有可能为勃起功能障碍提供一种新的治疗方法。此外，源自干细胞的细胞外囊泡可以发挥类似干细胞的再生作用，同时克服与细胞治疗相关的挑战，使其成为再生修复的优秀工具。因此，本文总结了不同干细胞来源的细胞外囊泡在治疗勃起功能障碍方面的潜力，并分析了它们的工程化临床前研究，以促进其从实验室到临床应用的转化。
