Tobita Morikuni, Arita Anna, Masubuchi Yosuke, Wakana Keiko, Yoneda Hikari, Namaki Shunsuke, Tamagawa Takaaki, Shinohara Mitsuyo
Juntendo Med J. 2025 Jun 6;71(4):238-246. doi: 10.14789/ejmj.JMJ24-0054-OA. eCollection 2025.
Platelet-rich plasma (PRP), obtained by centrifuging autologous blood, is widely used for pain relief and wound healing. PRP is also used in the dental field, but the safety and validity thereof for dental diseases have not yet been fully established. We aimed to evaluate the safety of PRP for the following dental procedures: post-extraction socket healing, maxillary sinus floor elevation, periodontal tissue regeneration, and intentional tooth replantation.
PRP was purified from patient's own venous blood and transplanted.
Eight patients were enrolled in clinical trials targeting four dental diseases, and subjected to the required treatment with transplantation (two patients/study). The primary endpoint was safety; specifically, adverse events after PRP treatment were evaluated based on clinical observations. Secondary endpoints were clinical evaluation, dental radiography and/or imaging evaluation, and platelet count.
No serious adverse events associated with the PRP transplantation were observed. In tooth extraction sockets, postoperative pain tended to subside the day after treatment. Regeneration of hard tissue at the PRP transplant site has been confirmed in clinical studies on maxillary sinus lifts, periodontal tissue regeneration, and tooth replantation.
Our findings demonstrate the safety and validity of PRP transplantation for each type of dental disease. Because the sample size was limited, further large-scale clinical studies are required to evaluate the safety and validity of PRP treatment for each dental disease.
通过离心自体血液获得的富血小板血浆（PRP）被广泛用于缓解疼痛和促进伤口愈合。PRP也用于牙科领域，但其对牙科疾病的安全性和有效性尚未完全确立。我们旨在评估PRP在以下牙科手术中的安全性：拔牙后牙槽窝愈合、上颌窦底提升、牙周组织再生和意向性牙齿再植。
从患者自身静脉血中纯化PRP并进行移植。
8名患者参加了针对4种牙科疾病的临床试验，并接受了所需的移植治疗（每项研究2名患者）。主要终点是安全性；具体而言，基于临床观察评估PRP治疗后的不良事件。次要终点是临床评估、牙科X线摄影和/或影像学评估以及血小板计数。
未观察到与PRP移植相关的严重不良事件。在拔牙窝中，术后疼痛在治疗后第二天趋于缓解。在上颌窦提升、牙周组织再生和牙齿再植的临床研究中，已证实PRP移植部位有硬组织再生。
我们的研究结果证明了PRP移植对每种牙科疾病的安全性和有效性。由于样本量有限，需要进一步开展大规模临床研究来评估PRP治疗每种牙科疾病的安全性和有效性。
