Kawaguchi S
Immunology. 1970 Aug;19(2):277-89.
Bovine γ-globulin induced immunological paralysis in adult mice when given in the deaggregated soluble form (sBGG). On the other hand, it elicited antibody production when given in the aggregated form (aBGG). These two forms of BGG were found to interfere with each other; in particular, the paralytogenic action of sBGG was disturbed by the simultaneous injection of aBGG. However, the injection of aBGG at least 1 day after sBGG could not reverse completely the paralytic state established by that time. X-irradiation was found to be effective in facilitating paralysis induction by the mixture of sBGG and aBGG which otherwise elicited immune response in unirradiated mice. The injection of sheep red blood cells (SRBC) prior to the injection of sBGG-aBGG mixture was also found to support the paralytogenic action of sBGG. Bacterial endotoxin (ET) prevented the paralysis induction by sBGG; rather it converted paralytogenic sBGG into immunogenic form. This effect of ET was augmented as the dose of sBGG increased. The effect of ET was not affected significantly by X-irradiation or SRBC administration.
牛γ球蛋白以去聚合可溶性形式（sBGG）给予成年小鼠时会诱导免疫麻痹。另一方面，以聚合形式（aBGG）给予时会引发抗体产生。发现这两种形式的BGG会相互干扰；特别是，同时注射aBGG会干扰sBGG的致麻痹作用。然而，在sBGG注射至少1天后注射aBGG不能完全逆转当时已建立的麻痹状态。发现X射线照射可有效促进sBGG和aBGG混合物诱导麻痹，否则该混合物会在未照射的小鼠中引发免疫反应。还发现，在注射sBGG - aBGG混合物之前注射绵羊红细胞（SRBC）可支持sBGG的致麻痹作用。细菌内毒素（ET）可阻止sBGG诱导麻痹；相反，它将致麻痹的sBGG转化为免疫原性形式。随着sBGG剂量增加，ET的这种作用增强。X射线照射或SRBC给药对ET的作用没有显著影响。
