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Studies on the induction of immunological paralysis to bovine gamma-globulin in adult mice. I. The competition between immunogen and paralytogen.成年小鼠对牛γ球蛋白免疫麻痹诱导的研究。I.免疫原与致瘫原之间的竞争
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2
Studies on the induction of immunological paralysis to bovine gamma-globulin in adult mice. I. The competition between immunogen and paralytogen.成年小鼠对牛γ球蛋白免疫麻痹诱导的研究。I.免疫原与致瘫原之间的竞争
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本文引用的文献

1
INHIBITION OF HEMAGGLUTININ SYNTHESIS BY CYTOXAN.环磷酰胺对血凝素合成的抑制作用
Cancer Res. 1965 Jun;25:745-51.
2
DOSE-RESPONSE RELATIONSHIPS FOR AGENTS INHIBITING THE IMMUNE RESPONSE.抑制免疫反应的药物的剂量-反应关系。
Immunology. 1964 Jan;7(1):65-71.
3
THE ROLE OF ANTIGEN DOSAGE IN DRUG-INDUCED IMMUNOLOGIC TOLERANCE.抗原剂量在药物诱导的免疫耐受中的作用。
J Immunol. 1963 May;90:703-10.
4
High specific activity iodination of gamma-globulin with iodine-131 monochloride.用一氯化碘-131对γ-球蛋白进行高比活度碘化。
Cancer Res. 1960 Nov;20:1495-1500.
5
Studies on cyclophosphamide-induced tolerance to sheep erythrocytes.环磷酰胺诱导对绵羊红细胞耐受性的研究。
J Exp Med. 1967 May 1;125(5):833-45. doi: 10.1084/jem.125.5.833.
6
The role of macrophages in the induction of antibody in x-irradiated animals.巨噬细胞在受X射线照射动物体内抗体诱导中的作用。
Immunology. 1967 Feb;12(2):197-206.
7
The immunogenic capacity of antigen taken up by peritoneal exudate cells.腹膜渗出细胞摄取的抗原的免疫原性能力。
Immunology. 1969 Jan;16(1):1-14.
8
A study of the 'termination' of tolerance to BSA with DNP-BSA in rabbits: relative affinities of the antibodies for the immunizing and the paralysing antigens.一项关于兔体内用二硝基苯牛血清白蛋白（DNP-BSA）终止对牛血清白蛋白（BSA）耐受性的研究：抗体对免疫抗原和麻痹抗原的相对亲和力。
Immunology. 1967 Aug;13(2):147-57.
9
The mechanism of immunological paralysis.免疫麻痹的机制。
Adv Immunol. 1968;8:129-81. doi: 10.1016/s0065-2776(08)60466-6.
10
Tolerance.耐受性
Annu Rev Microbiol. 1967;21:157-80. doi: 10.1146/annurev.mi.21.100167.001105.

成年小鼠对牛γ球蛋白免疫麻痹诱导的研究。II. 环磷酰胺的作用。

Studies on the induction of immunological paralysis to bovine gamma-globulin in adult mice. II. The effect of cyclophosphamide.

作者信息

Kawaguchi S

出版信息

Immunology. 1970 Aug;19(2):291-9.

PMID:4097111
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1455761/
Abstract

The immune response elicited by immunogenic forms of bovine γ-globulin (BGG), such as heat aggregated BGG (aBGG), BGG in Freund's incomplete adjuvant (FIA) or BGG plus endotoxin (ET), was interrupted by a single injection of cyclophosphamide. The amount of soluble BGG (sBGG) required to induce paralysis did not differ significantly between cyclophosphamide-treated mice and untreated mice. The injection of 1 mg sBGG together with 100 μg aBGG or 10 μg ET caused an immune response in normal mice but induced paralysis in cyclophosphamide-treated mice. However, without sBGG, the administration of aBGG suspension or aBGG in FIA could not induce paralysis, even with the aid of cyclophosphamide.

摘要

由免疫原性形式的牛γ球蛋白（BGG）引发的免疫反应，如热聚集BGG（aBGG）、弗氏不完全佐剂（FIA）中的BGG或BGG加内毒素（ET），可通过单次注射环磷酰胺而被阻断。诱导麻痹所需的可溶性BGG（sBGG）量在环磷酰胺处理的小鼠和未处理的小鼠之间没有显著差异。在正常小鼠中，注射1 mg sBGG与100 μg aBGG或10 μg ET一起会引发免疫反应，但在环磷酰胺处理的小鼠中会诱导麻痹。然而，没有sBGG时，即使借助环磷酰胺，给予aBGG悬浮液或FIA中的aBGG也不能诱导麻痹。