成年小鼠对牛γ球蛋白免疫麻痹诱导的研究。II. 环磷酰胺的作用。
Studies on the induction of immunological paralysis to bovine gamma-globulin in adult mice. II. The effect of cyclophosphamide.
作者信息
Kawaguchi S
出版信息
Immunology. 1970 Aug;19(2):291-9.
The immune response elicited by immunogenic forms of bovine γ-globulin (BGG), such as heat aggregated BGG (aBGG), BGG in Freund's incomplete adjuvant (FIA) or BGG plus endotoxin (ET), was interrupted by a single injection of cyclophosphamide. The amount of soluble BGG (sBGG) required to induce paralysis did not differ significantly between cyclophosphamide-treated mice and untreated mice. The injection of 1 mg sBGG together with 100 μg aBGG or 10 μg ET caused an immune response in normal mice but induced paralysis in cyclophosphamide-treated mice. However, without sBGG, the administration of aBGG suspension or aBGG in FIA could not induce paralysis, even with the aid of cyclophosphamide.
由免疫原性形式的牛γ球蛋白（BGG）引发的免疫反应，如热聚集BGG（aBGG）、弗氏不完全佐剂（FIA）中的BGG或BGG加内毒素（ET），可通过单次注射环磷酰胺而被阻断。诱导麻痹所需的可溶性BGG（sBGG）量在环磷酰胺处理的小鼠和未处理的小鼠之间没有显著差异。在正常小鼠中，注射1 mg sBGG与100 μg aBGG或10 μg ET一起会引发免疫反应，但在环磷酰胺处理的小鼠中会诱导麻痹。然而，没有sBGG时，即使借助环磷酰胺，给予aBGG悬浮液或FIA中的aBGG也不能诱导麻痹。
Zotero 插件