Mussayev Abdurashid, Freeman Phillip, Raissov Yerkezhan, Otarbayev Yerik, Abikeyeva Lyazzat, Kali Aknur, Lesbekov Timur, Baigalganova Almira, Akhanov Nurbol, Pya Yuriy
Department of Interventional Cardiology, Heart Center University Medical Center, Astana, Kazakhstan.
Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark.
JACC Case Rep. 2025 Sep 17;30(28):105094. doi: 10.1016/j.jaccas.2025.105094.
The LAMPOON (laceration of the anterior mitral leaflet to prevent outflow obstruction) procedure is an innovative transcatheter technique designed to prevent left ventricular outflow tract obstruction during transcatheter mitral valve interventions.
A 14-year-old male patient with a history of infective endocarditis, previously treated with surgical aortic valve replacement and mitral annuloplasty, presented with severe mitral regurgitation and decompensated heart failure. Owing to prohibitive surgical risk, a transcatheter mitral valve-in-ring replacement (TMViR) was performed with adjunctive LAMPOON to prevent left ventricular outflow tract obstruction. This is to our knowledge the first reported pediatric case of TMViR facilitated by LAMPOON. The procedure was technically successful, and the patient recovered without major complications.
This case highlights a novel application of LAMPOON in the pediatric population. Given the absence of surgical options, this approach offers a life-saving, minimally invasive alternative and expands the role of structural interventions in children with complex valvular disease.
TAKE-HOME MESSAGES: LAMPOON can enable safe TMViR in high-risk pediatric patients. Successful outcomes require careful planning, imaging, and multidisciplinary coordination.
二尖瓣前叶撕裂预防流出道梗阻(LAMPOON)手术是一种创新的经导管技术,旨在预防经导管二尖瓣介入治疗期间的左心室流出道梗阻。
一名14岁男性患者,有感染性心内膜炎病史,此前接受过外科主动脉瓣置换术和二尖瓣环成形术,现出现严重二尖瓣反流和失代偿性心力衰竭。由于手术风险过高,进行了经导管二尖瓣环内置换术(TMViR)并辅助LAMPOON手术以预防左心室流出道梗阻。据我们所知,这是首例报道的采用LAMPOON辅助的小儿TMViR病例。手术在技术上取得成功,患者康复且无重大并发症。
该病例突出了LAMPOON在儿科患者中的新应用。鉴于缺乏手术选择,这种方法提供了一种挽救生命的微创替代方案,并扩大了结构性干预在患有复杂瓣膜疾病儿童中的作用。
LAMPOON可使高危儿科患者安全进行TMViR。成功的结果需要精心规划、影像学检查和多学科协作。