Naseri Aida, Razi Sepideh, Rezaei Nima
Cancer Immunology Project (CIP), Universal Scientific Education and Research Network (USERN), Tehran, Iran.
Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Clin Transl Oncol. 2025 Sep 19. doi: 10.1007/s12094-025-04058-x.
Gliomas present a significant challenge to modern medicine as some of the most diverse and malignant brain tumors. Despite considerable developments in curative measures, the prognosis remains unsatisfactory. A prime reason is that much is obscured about the genetic regulation of glioma pathogenesis. In recent years, specificity protein 1 (Sp1) has been recognized as a central transcription factor that promotes gliomagenesis. Sp1, which is overexpressed in glioma tissues, modulates gene transcription by targeting GC boxes through its zinc finger motifs. As a result, it can influence tumor formation, proliferation, invasion, and distant migration. The present review summarizes the structure, function, and regulation of Sp1. Furthermore, this study elucidates the underlying mechanism by which Sp1 interacts with signaling pathways to fuel tumor growth and chemoresistance. Finally, the current state of Sp1's clinical implications is outlined. These findings reveal the potential benefits of Sp1 as a therapeutic target and diagnostic tool, laying the foundation for future studies.
神经胶质瘤作为一些最多样化和最恶性的脑肿瘤，对现代医学构成了重大挑战。尽管在治疗措施方面取得了相当大的进展，但预后仍然不尽人意。一个主要原因是，关于神经胶质瘤发病机制的基因调控仍有很多不明确之处。近年来，特异性蛋白1（Sp1）已被公认为促进神经胶质瘤发生的核心转录因子。Sp1在神经胶质瘤组织中过度表达，通过其锌指基序靶向GC盒来调节基因转录。因此，它可以影响肿瘤的形成、增殖、侵袭和远处转移。本综述总结了Sp1的结构、功能和调控。此外，本研究阐明了Sp1与信号通路相互作用以促进肿瘤生长和化疗耐药性的潜在机制。最后，概述了Sp1临床意义的现状。这些发现揭示了Sp1作为治疗靶点和诊断工具的潜在益处，为未来的研究奠定了基础。
