Bishoyi Ashok Kumar, Al-Hasnaawei Shaker, Ganesan Subbulakshmi, Shankhyan Aman, Nanda Anima, Sinha Aashna, Ray Subhashree, Nathiya Deepak
Faculty of Science, Department of Microbiology, Marwadi University Research Center, Marwadi University, Rajkot, Gujarat, India.
College of Pharmacy, The Islamic University, Najaf, Iraq.
Med Oncol. 2025 Sep 20;42(11):483. doi: 10.1007/s12032-025-03044-1.
Ovarian cancer remains one of the most lethal malignancies affecting women, largely due to its asymptomatic onset and frequent diagnosis at advanced stages. Emerging evidence has underscored the pivotal role of kinesin superfamily proteins (KIFs) in orchestrating the cellular mechanisms underlying tumor initiation and progression, particularly in ovarian cancer. These microtubule-associated motor proteins are essential for intracellular transport, cell division, signal transduction, and organelle positioning. Dysregulation of KIFs has been implicated in enhanced cellular proliferation, metastasis, and resistance to chemotherapy. In ovarian cancer, specific KIF members have been shown to promote cell motility and interfere with key signaling pathways, thereby accelerating tumor progression. Elevated expression levels of certain KIFs correlate with poor patient prognosis and reduced overall survival. This review consolidates current insights into the role of KIFs in ovarian cancer pathogenesis and emphasizes their potential as therapeutic targets. Elucidating the mechanistic involvement of KIFs in this malignancy may pave the way for innovative diagnostic, prognostic, and therapeutic strategies aimed at improving clinical outcomes in this highly aggressive cancer type.
卵巢癌仍然是影响女性的最致命恶性肿瘤之一，这主要归因于其无症状起病以及在晚期阶段才频繁被诊断出来。新出现的证据强调了驱动蛋白超家族蛋白（KIFs）在协调肿瘤起始和进展的细胞机制中所起的关键作用，尤其是在卵巢癌中。这些与微管相关的运动蛋白对于细胞内运输、细胞分裂、信号转导和细胞器定位至关重要。KIFs的失调与细胞增殖增强、转移以及化疗耐药性有关。在卵巢癌中，特定的KIF成员已被证明可促进细胞运动并干扰关键信号通路，从而加速肿瘤进展。某些KIFs的表达水平升高与患者预后不良和总生存期缩短相关。本综述汇总了目前对KIFs在卵巢癌发病机制中的作用的见解，并强调了它们作为治疗靶点的潜力。阐明KIFs在这种恶性肿瘤中的机制性参与可能为旨在改善这种高度侵袭性癌症类型临床结局的创新诊断、预后和治疗策略铺平道路。
