Özdoğan Bircan Ayşegül, Zengin Acemoğlu Şerife Şeyda, Türk İpek, Elbek Özer Hüseyin Turgut
Division of Rheumatology, Department of Internal Medicine, Çukurova University Faculty of Medicine, Adana, Türkiye.
Arch Rheumatol. 2025 Sep 1;40(3):376-382. doi: 10.5152/ArchRheumatol.2025.25012.
Background/Aims: Primary Sjögren's syndrome (pSS) is an autoimmune disease that can affect several systems. The purpose of this study was to examine the connection between primary Sjögren's disease activity and the CRP-albumin-lymphocyte index (CALLY) and the HALP (hemoglobin, albumin, lymphocyte, and platelet) score, 2 novel immunonutritional indicators that have not yet been applied to rheumatological disease activation. Materials and Methods: This cross-sectional study included 89 patients with pSS and 113 age- and sex-matched individuals. The relationship between haematological, inflammatory, immunonutritional biomarkers, and disease activation was investigated, as were the differences between the groups. Results: Eighty-nine patients (96.6% female, mean age 53.4 ± 15.0 years) and 113 control subjects (97.3% female, mean age 50.8 ± 14.9 years) were included in the study. The levels of C-reactive protein (CRP), erythrocyte sedimentation rate, red cell distribution width, neutrophil lymphocyte ratio, monocyte lymphocyte ratio, platelet lymphocyte ratio, and C-reactive protein albumin ratio were significantly higher in the group of patients with pSS compared to the control group (all; P < .001). Systemic immuneinflammation index and systemic inflammatory response index were significantly elevated in the patient cohort compared to the control group (P = .002 and P = .048, respectively). The CALLY index and HALP score were negatively correlated with EULAR Sjögren's syndrome disease activity index (P < .001 for both). Conclusion: The CALLY index and HALP score represent a novel approach to assessing disease activity and prognosis in a number of conditions, including stroke, myocardial infarction, osteoarthritis, pulmonary thromboembolism, asthma, chronic obstructive pulmonary disease, and many types of cancer. They may also be useful as a guide to disease activity and monitoring in pSS.
背景/目的：原发性干燥综合征（pSS）是一种可累及多个系统的自身免疫性疾病。本研究旨在探讨原发性干燥综合征疾病活动度与CRP-白蛋白-淋巴细胞指数（CALLY）和HALP（血红蛋白、白蛋白、淋巴细胞和血小板）评分之间的联系，这两个新的免疫营养指标尚未应用于风湿病疾病活动度评估。材料与方法：这项横断面研究纳入了89例pSS患者和113例年龄及性别匹配的个体。研究了血液学、炎症、免疫营养生物标志物与疾病活动度之间的关系以及两组之间的差异。结果：本研究纳入了89例患者（女性占96.6%，平均年龄53.4±15.0岁）和113例对照者（女性占97.3%，平均年龄50.8±14.9岁）。与对照组相比，pSS患者组的C反应蛋白（CRP）、红细胞沉降率、红细胞分布宽度、中性粒细胞淋巴细胞比值、单核细胞淋巴细胞比值、血小板淋巴细胞比值和C反应蛋白白蛋白比值均显著升高（均P<0.001）。与对照组相比，患者队列中的全身免疫炎症指数和全身炎症反应指数显著升高（分别为P = 0.002和P = 0.048）。CALLY指数和HALP评分与欧洲抗风湿病联盟（EULAR）干燥综合征疾病活动指数呈负相关（两者均P<0.001）。结论：CALLY指数和HALP评分代表了一种评估多种疾病（包括中风、心肌梗死、骨关节炎、肺血栓栓塞、哮喘、慢性阻塞性肺疾病和多种癌症）疾病活动度和预后的新方法。它们也可能有助于指导pSS的疾病活动度评估和监测。
