评估暴露于牙周病原体的牙龈成纤维细胞的细胞因子释放情况。
assessment of cytokine release from gingival fibroblasts exposed to periodontal pathogens.
作者信息
Tripathi Kaushal Pati, Mishra Rohit, Choubey Varsha, Kumar Ajay, Aglawe Arohi, Gulati Anshul
机构信息
Department of Periodontics & Implantology, Hitkarini Dental College & Hospital, Jabalpur 482005, Madhya Pradesh, India.
Department of Oral Medicine & Radiology, Faculty of Dental Sciences, Institute of Medical Sciences, Banaras Hindu University, Varanasi-221005, Uttar Pradesh, India.
出版信息
Bioinformation. 2025 Jun 30;21(6):1501-1505. doi: 10.6026/973206300211501. eCollection 2025.
Abstract
Cytokine responses of gingival fibroblasts from healthy and inflamed tissues upon exposure to (LPS) are of interest. Samples were obtained from 20 individuals undergoing periodontal procedures. Inflamed fibroblasts showed elevated secretion of IL-6, MCP-1, IL-8, and GRO. LPS induced a stronger cytokine response than controls. Thus, inflamed fibroblasts can mount a secondary inflammatory response to periodontal pathogens.
摘要
来自健康和发炎组织的牙龈成纤维细胞在暴露于脂多糖（LPS）时的细胞因子反应备受关注。样本取自20名接受牙周治疗的个体。发炎的成纤维细胞显示出白细胞介素-6（IL-6）、单核细胞趋化蛋白-1（MCP-1）、白细胞介素-8（IL-8）和生长调节致癌基因α（GRO）分泌增加。脂多糖诱导的细胞因子反应比对照组更强。因此，发炎的成纤维细胞可对牙周病原体产生继发性炎症反应。
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本文引用的文献
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Clin Oral Investig. 2018 Mar;22(2):919-927. doi: 10.1007/s00784-017-2171-6. Epub 2017 Jul 8.
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Differential cytokine patterns in mouse macrophages and gingival fibroblasts after stimulation with porphyromonas gingivalis or Escherichia coli lipopolysaccharide.牙龈卟啉单胞菌或大肠杆菌脂多糖刺激后小鼠巨噬细胞和牙龈成纤维细胞中细胞因子的差异模式。
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