Barillot Lila, Chauvet Claudia, Chauchard Emeline, Besnier Marc, Harika-Germaneau Ghina, Noël Xavier, Jaafari Nemat, Solinas Marcello, Chatard Armand
Université de Poitiers, Centre National de la Recherche Scientifique (CNRS) 7295, Centre de Recherches sur la Cognition et l'Apprentissage, Poitiers, France.
Unité de Recherche Clinique, Centre Hospitalier Laborit, Poitiers, France.
Front Behav Neurosci. 2025 Sep 5;19:1629918. doi: 10.3389/fnbeh.2025.1629918. eCollection 2025.
Preclinical studies have shown that exposure to a multisensory, stimulating environment (environmental enrichment, EE) can prevent the development of addictive behaviors and reduce the risk of relapse in animal models. However, the extent to which these preclinical findings apply to human addiction remains largely unknown. In this research, we investigated the role of EE in human substance use disorders (SUDs).
A new self-report measure of perceived EE was developed to test, in human participants, whether EE is associated with lower levels of SUD. This scale was administered to two distinct groups: regular smokers ( = 286) and patients diagnosed with severe alcohol use disorder ( = 52). Smokers also provided demographic information and data on nicotine use, while patients with alcohol use disorder reported pre-hospitalization drug intake, detoxification history, and levels of depression and anxiety.
The EE scale demonstrated adequate psychometric properties, including a stable factorial structure and high test-retest reliability over 1 month. Among smokers, higher scores were significantly associated with lower nicotine consumption, dependence and craving. In patients with alcohol use disorder, lower scores were linked to a history of more frequent relapse. These effects were independent from depression and anxiety.
Environmental enrichment, as perceived and self-reported by individuals, appears to be a promising construct for understanding vulnerability and resilience in human addiction. The scale may serve as a valuable translational tool between preclinical and clinical models, with potential implications for the development of new intervention strategies for SUD.
临床前研究表明，置身于多感官刺激环境（环境富集，EE）中可预防成瘾行为的发展，并降低动物模型中的复发风险。然而，这些临床前研究结果在多大程度上适用于人类成瘾情况在很大程度上仍不明确。在本研究中，我们调查了环境富集在人类物质使用障碍（SUDs）中的作用。
开发了一种新的自我报告的感知环境富集测量方法，以测试在人类参与者中环境富集是否与较低水平的物质使用障碍相关。该量表应用于两个不同的群体：经常吸烟者（n = 286）和被诊断为重度酒精使用障碍的患者（n = 52）。吸烟者还提供了人口统计学信息和尼古丁使用数据，而酒精使用障碍患者报告了住院前的药物摄入、戒毒史以及抑郁和焦虑水平。
环境富集量表显示出良好的心理测量特性，包括稳定的因子结构和超过1个月的高重测信度。在吸烟者中，较高的分数与较低的尼古丁消费量、依赖性和渴望显著相关。在酒精使用障碍患者中，较低的分数与更频繁的复发史相关。这些影响独立于抑郁和焦虑。
个体感知和自我报告的环境富集似乎是理解人类成瘾易感性和恢复力的一个有前景的概念。该量表可作为临床前和临床模型之间有价值的转化工具，对物质使用障碍新干预策略的开发具有潜在意义。
