Shen Wei-Cheng, Cheng Hsu-Tang, Jan Yih-Kuen, Liau Ben-Yi, Lien Chun-Ming, Bau Jian-Guo, Chao Wen-Hung, Ching Congo T, Lung Chi-Wen
Department of Creative Product Design, Asia University, Taichung, TWN.
Department of Surgery, Asia University Hospital, Taichung, TWN.
Cureus. 2025 Aug 18;17(8):e90436. doi: 10.7759/cureus.90436. eCollection 2025 Aug.
Skin blood flow is crucial for transporting nutrients during healing and treating scarring. Negative-pressure therapy (NPT) is a promising option for enhancing skin blood flow. However, the most effective dosage of NPT for treating scars remains unclear. This study aimed to investigate the effect of different dosages of NPT on skin blood flow before and after treatment.
In this study, 36 participants with scars were recruited to assess the efficacy of various NPT interventions. NPT was administered at three different dosages: -105, -125, and -145 mmHg for 10 min. The perfusion level is defined as the amount of blood flowing through the skin (SBF). In NPT, SBF was measured before treatment (SBF-Baseline), during treatment (SBF-Application), and after treatment (SBF-Termination).
SBF-Termination at -105 mmHg NPT (152.7 ± 33.7 perfusion units (PU)) showed a significantly higher SBF than at -125 mmHg NPT (77.5 ± 19.2 PU, P = 0.026) or -145 mmHg NPT (65.2 ± 12.7 PU, P = 0.012). Statistical relevance was found at -105 mmHg NPT between SBF-Application and SBF-Termination (r=0.890,P < 0.001).
This study indicates that a -105 mmHg NPT dosage can effectively increase SBF. Our research contributes to the emerging field of scar treatment and provides evidence-based recommendations.
皮肤血流对于愈合过程中营养物质的输送以及瘢痕治疗至关重要。负压疗法（NPT）是增强皮肤血流的一种有前景的选择。然而，用于治疗瘢痕的NPT最有效剂量仍不明确。本研究旨在探讨不同剂量的NPT对治疗前后皮肤血流的影响。
在本研究中，招募了36名有瘢痕的参与者来评估各种NPT干预措施的疗效。NPT以三种不同剂量施用：-105、-125和-145 mmHg，持续10分钟。灌注水平定义为流经皮肤的血液量（皮肤血流量，SBF）。在NPT中，在治疗前（SBF-基线）、治疗期间（SBF-施用）和治疗后（SBF-终止）测量SBF。
-105 mmHg NPT治疗后的SBF-终止值（152.7±33.7灌注单位（PU））显示出比-125 mmHg NPT（77.5±19.2 PU，P = 0.026）或-145 mmHg NPT（65.2±12.7 PU，P = 0.012）显著更高的SBF。在-105 mmHg NPT下，SBF-施用和SBF-终止之间存在统计学相关性（r = 0.890，P < 0.001）。
本研究表明，-105 mmHg的NPT剂量可有效增加SBF。我们的研究为瘢痕治疗这一新兴领域做出了贡献，并提供了循证建议。
