皮肤病中的循环CLA记忆性T细胞：转化医学视角
Circulating CLA Memory T Cells in Skin Diseases: A Translational Perspective.
作者信息
Czarnowicki Tali, Tordjman Lea, García-Jiménez Irene, Santamaria-Babí Luis F
机构信息
Dr Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA.
University of Miami Miller School of Medicine, Miami, Florida, USA.
出版信息
JID Innov. 2025 Aug 5;5(6):100403. doi: 10.1016/j.xjidi.2025.100403. eCollection 2025 Nov.
Circulating cutaneous lymphocyte-associated antigen-positive T cells constitute a subset of memory T cells with a unique phenotype, effector function, and therapeutic relevance because they reflect the regional functions of the cutaneous immune system. These cells are involved in the pathological mechanisms of diverse cutaneous diseases. This review brings updated translational insights into these cells and identifies key questions for future research in the field.
循环中的皮肤淋巴细胞相关抗原阳性T细胞构成了记忆T细胞的一个亚群，具有独特的表型、效应功能和治疗相关性，因为它们反映了皮肤免疫系统的区域功能。这些细胞参与多种皮肤疾病的病理机制。本综述带来了对这些细胞的最新转化见解，并确定了该领域未来研究的关键问题。
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