Patil Shiv, Patel Nirmal, Teichner Eric, Lee William, Ranjbar Ehsan, Gerlach Alexander, Subtirelu Robert, Herpin Lancelot, Werner Thomas, Høilund-Carlsen Poul Flemming, Alavi Abass
Department of Radiology, University of Pennsylvania Philadelphia, PA, USA.
Sidney Kimmel Medical College, Thomas Jefferson University Philadelphia, PA, USA.
Am J Nucl Med Mol Imaging. 2025 Aug 15;15(4):153-157. doi: 10.62347/IXKG9158. eCollection 2025.
Osteoporosis is a highly prevalent skeletal disease involving a pathophysiology of altered bone turnover. Positron emission tomography (PET)/computed tomography (CT) imaging with F-sodium fluoride (NaF) can visualize metabolic alterations in bone that precede clinical manifestations or structural alterations and thus may serve a role in the early detection and monitoring of osteoporosis. We present two non-oncological case reports demonstrating different metabolic changes in early and advanced disease stages as assessed by F-NaF PET/CT that cannot be appreciated by conventional structural imaging alone, supporting a potential clinical application of F-NaF PET/CT for early detection and monitoring of osteoporosis in the lumbar spine.
骨质疏松症是一种高度流行的骨骼疾病，涉及骨转换改变的病理生理学。使用氟-氟化钠（NaF）的正电子发射断层扫描（PET）/计算机断层扫描（CT）成像可以可视化在临床表现或结构改变之前的骨骼代谢变化，因此可能在骨质疏松症的早期检测和监测中发挥作用。我们展示了两例非肿瘤病例报告，通过F-NaF PET/CT评估显示了疾病早期和晚期不同的代谢变化，这是仅通过传统结构成像无法察觉的，支持了F-NaF PET/CT在腰椎骨质疏松症早期检测和监测中的潜在临床应用。
