Miller A B, Nunn A J, Robinson D K, Ferguson G C, Fox W, Tall R
Bull World Health Organ. 1970;43(1):107-25.
As part of a large-scale international, co-operative investigation into the side-effects produced by thioacetazone employed in the treatment of tuberculosis, an evaluation has been made of a supplement incorporating vitamins and an antihistamine as a prophylactic.Over a 12-week period of treatment, the additive supplement failed to reduce the over-all frequency of side-effects or the frequency of side-effects leading to a major departure from prescribed treatment. There was also no evidence that the more serious side-effects, particularly rashes, jaundice and agranulocytosis, were reduced by the additives, although the occurrence of vomiting, which was however infrequent, was reduced.In view of this lack of appreciable benefit, as well as the higher cost and impaired keeping properties of tablets containing thioacetazone plus isoniazid when the supplement is added, the use of the supplement as a prophylactic cannot be recommended.
作为对用于治疗结核病的氨硫脲所产生副作用进行大规模国际合作调查的一部分，对一种含有维生素和抗组胺药作为预防剂的补充剂进行了评估。在为期12周的治疗期间，添加的补充剂未能降低副作用的总体发生率或导致严重偏离规定治疗的副作用发生率。也没有证据表明添加剂能减少更严重的副作用，特别是皮疹、黄疸和粒细胞缺乏症，尽管呕吐（虽然不常见）的发生率有所降低。鉴于缺乏明显益处，以及添加补充剂后含氨硫脲加异烟肼片剂成本更高且保存性能受损，不建议将该补充剂用作预防剂。
