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An International Working Group viewpoint on stratifying risk and prevention of the clinical expression of Alzheimer's disease.

作者信息

Feldman Howard H, Villain Nicolas, Frisoni Giovanni B, Dubois Bruno

机构信息

Alzheimer's Disease Cooperative Study, University of California San Diego, School of Medicine, La Jolla, CA, USA.

Department of Neurosciences, University of California San Diego, La Jolla, CA, USA.

出版信息

Nat Aging. 2025 Oct;5(10):1930-1932. doi: 10.1038/s43587-025-00977-0.

DOI:10.1038/s43587-025-00977-0
PMID:40983695
Abstract
摘要

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本文引用的文献

1
Alzheimer Disease as a Clinical-Biological Construct-An International Working Group Recommendation.作为一种临床生物学概念的阿尔茨海默病——国际工作组建议
JAMA Neurol. 2024 Dec 1;81(12):1304-1311. doi: 10.1001/jamaneurol.2024.3770.
2
2024 AA criteria for Alzheimer's disease diagnosis: Mainly anchored at Aβ not tau.2024年阿尔茨海默病诊断的AA标准:主要基于淀粉样蛋白β而非tau蛋白。
Alzheimers Dement. 2024 Dec;20(12):9079-9081. doi: 10.1002/alz.14340. Epub 2024 Oct 29.
3
Challenges in a Biological Definition of Alzheimer Disease.阿尔茨海默病生物学定义面临的挑战。
Neurology. 2024 Nov 12;103(9):e209884. doi: 10.1212/WNL.0000000000209884. Epub 2024 Oct 1.
4
Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission.《痴呆症的预防、干预与照护:柳叶刀常设委员会2024年报告》
Lancet. 2024 Aug 10;404(10452):572-628. doi: 10.1016/S0140-6736(24)01296-0. Epub 2024 Jul 31.
5
Revised criteria for diagnosis and staging of Alzheimer's disease: Alzheimer's Association Workgroup.修订的阿尔茨海默病诊断和分期标准:阿尔茨海默病协会工作组。
Alzheimers Dement. 2024 Aug;20(8):5143-5169. doi: 10.1002/alz.13859. Epub 2024 Jun 27.
6
APOE4 homozygozity represents a distinct genetic form of Alzheimer's disease.载脂蛋白 E4 纯合子代表一种独特的阿尔茨海默病遗传形式。
Nat Med. 2024 May;30(5):1284-1291. doi: 10.1038/s41591-024-02931-w. Epub 2024 May 6.
7
Dementia prevention in memory clinics: recommendations from the European task force for brain health services.记忆门诊中的痴呆症预防:欧洲脑健康服务特别工作组的建议
Lancet Reg Health Eur. 2023 Jan 31;26:100576. doi: 10.1016/j.lanepe.2022.100576. eCollection 2023 Mar.
8
Amyloid and tau PET-positive cognitively unimpaired individuals are at high risk for future cognitive decline.淀粉样蛋白和 tau 正电子发射断层扫描(PET)阳性、认知正常的个体未来认知能力下降的风险较高。
Nat Med. 2022 Nov;28(11):2381-2387. doi: 10.1038/s41591-022-02049-x. Epub 2022 Nov 10.
9
Racial and Ethnic Differences in Amyloid PET Positivity in Individuals With Mild Cognitive Impairment or Dementia: A Secondary Analysis of the Imaging Dementia-Evidence for Amyloid Scanning (IDEAS) Cohort Study.轻度认知障碍或痴呆个体中淀粉样蛋白PET阳性的种族和民族差异:淀粉样蛋白扫描成像痴呆证据(IDEAS)队列研究的二次分析
JAMA Neurol. 2022 Oct 3;79(11):1139-47. doi: 10.1001/jamaneurol.2022.3157.
10
Penetrance estimation of Alzheimer disease in SORL1 loss-of-function variant carriers using a family-based strategy and stratification by APOE genotypes.采用基于家系的策略和 APOE 基因型分层,对 SORL1 功能丧失变异携带者的阿尔茨海默病外显率进行估计。
Genome Med. 2022 Jun 28;14(1):69. doi: 10.1186/s13073-022-01070-6.