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Ilizarov骨搬运治疗难治性骨髓炎胫骨远端缺损的临床疗效:一项回顾性研究

Clinical Outcomes of Ilizarov Bone Transport for Distal Tibial Defects in Refractory Osteomyelitis: A Retrospective Study.

作者信息

Alimujiang Abudusalamu, Jia Qiyu, Guo Jian, Zhang Jun, Wang Xi, Zhao Meng, Ouzhabayier Meidege, Wang Yingbo, Ma Chuang

机构信息

Department of Trauma Orthopedics, the First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, People's Republic of China.

Department of Rehabilitation Medicine, the First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, People's Republic of China.

出版信息

Ther Clin Risk Manag. 2025 Sep 17;21:1369-1382. doi: 10.2147/TCRM.S525768. eCollection 2025.

Abstract

BACKGROUND

Distal tibial defects following refractory osteomyelitis pose a significant orthopedic challenge, necessitating effective reconstruction. The Ilizarov bone transport technique is a potential treatment option, but its clinical outcomes specifically for distal tibial infectious defects need further evaluation.

METHODS

In this retrospective observational single-arm study, we analyzed the clinical data of 22 patients who had undergone multiple debridements for refractory distal tibial osteomyelitis (DTO) and had associated bone defects, and were subsequently treated with the Ilizarov bone transport technique. Following debridement surgery, bone transport treatment was administered. Regular X-ray examinations, rehabilitation guidance, and follow-up were conducted to assess infection control, bone healing, limb function recovery, and complications. Therapeutic effects were evaluated using the Association for the Study and Application of Methods of Ilizarov (ASAMI), Visual Analog Scale (VAS) score, Activities of Daily Living (ADL) score, and American Orthopaedic Foot & Ankle Society (AOFAS) score improvement.

RESULTS

The mean follow-up was 29.32±20.92 months, with an average of 3.77±1.83 debridements. All bone defects healed, though 5 patients later required ankle arthrodesis. Complications included pin tract infection (n=10), axial deviation (n=3), ankle joint stiffness (n=2), non-union at the docking site (n=2), and delayed consolidation (n=2). At the last follow-up, ASAMI bone results: 15 excellent, 5 good, 2 poor (90.9% superiority rate). ASAMI functional results: 6 excellent, 14 good, 1 fair, 1 poor (90.9% superiority rate). VAS decreased from 4.86±0.83 to 0.5±0.66 (p<0.001). ADL improved from 80 (78.75-85) to 92.5 (90-95) (p<0.001). AOFAS score increased from 32 (25-38.25) to 82 (77-87.5) (p<0.001), with an 86.4% overall superiority rate.

CONCLUSION

Bone transport post - debridement is a valuable salvage for reconstructing distal tibial defects post-refractory osteomyelitis, with high safety, healing rate, and good efficacy. However, further comparative studies are warranted to confirm its advantages over other treatments.

摘要

背景

难治性骨髓炎后的胫骨远端缺损给骨科带来了重大挑战,需要进行有效的重建。伊里扎洛夫骨搬运技术是一种潜在的治疗选择,但其针对胫骨远端感染性缺损的临床疗效需要进一步评估。

方法

在这项回顾性观察单臂研究中,我们分析了22例因难治性胫骨远端骨髓炎(DTO)接受多次清创且伴有骨缺损,随后接受伊里扎洛夫骨搬运技术治疗的患者的临床资料。清创手术后,进行骨搬运治疗。定期进行X线检查、康复指导和随访,以评估感染控制情况、骨愈合情况、肢体功能恢复情况及并发症。使用伊里扎洛夫方法研究与应用协会(ASAMI)、视觉模拟评分(VAS)、日常生活活动能力(ADL)评分以及美国矫形足踝协会(AOFAS)评分改善情况来评估治疗效果。

结果

平均随访时间为29.32±20.92个月,平均清创次数为3.77±1.83次。所有骨缺损均愈合,不过5例患者后来需要进行踝关节融合术。并发症包括针道感染(n = 10)、轴向偏移(n = 3)、踝关节僵硬(n = 2)、对接部位骨不连(n = 2)以及延迟愈合(n = 2)。在最后一次随访时,ASAMI骨结果:15例优,5例良,2例差(优良率90.9%)。ASAMI功能结果:6例优,14例良,1例可,1例差(优良率90.9%)。VAS评分从4.86±0.83降至0.5±0.66(p < 0.001)。ADL评分从80(78.75 - 85)提高到92.5(90 - 95)(p < 0.001)。AOFAS评分从32(25 - 38.25)提高到82(77 - 87.5)(p < 0.001),总体优良率为86.4%。

结论

清创后骨搬运是重建难治性骨髓炎后胫骨远端缺损的一种有价值的挽救方法,安全性高、愈合率高且疗效良好。然而,需要进一步的对比研究来证实其相对于其他治疗方法的优势。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/745b/12450385/aad00b610483/TCRM-21-1369-g0001.jpg

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